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Antibody development after COVID-19 vaccination in patients with autoimmune diseases in the Netherlands: a substudy of data from two prospective cohort studies

Antibody development after COVID-19 vaccination in patients with autoimmune diseases in the Netherlands: a substudy of data from two prospective cohort studies
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Merck Serono , Bayer Schering Pharma , Biogen Idec , Netherlands Trial Register , மெர்க் செரோனோ , பேயர் ஶரிஂக் பார்மா , பயோஜென் ஐடெக் , நெதர்லாந்து சோதனை பதிவு ,

NMD Pharma Doses the First Myasthenia Gravis Patient in a Combined Phase I/IIa Clinical Trial of NMD670 | Small Molecules

NMD Pharma Doses the First Myasthenia Gravis Patient in a Combined Phase I/IIa Clinical Trial of NMD670 | Small Molecules
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United States , Geert Jan Groeneveld , Thomas Holm Pedersen , Centre For Human Drug Research , European Union , Roche Venture Fund , Aarhus University , First Myasthenia Gravis Patient , Combined Phase , Clinical Trial , Denmarki June , Holm Pedersen , Chief Executive Officer , Chief Scientific Officer , Chief Medical Officer , Human Drug Research , Principal Investigator , Netherlands Trial Register , Enovo Seeds , Lundbeckfonden Emerge , Myasthenia Gravis , ஒன்றுபட்டது மாநிலங்களில் , தாமஸ் ஹோல்ம் பெடர்‌ஸெந் , மையம் க்கு மனிதன் மருந்து ஆராய்ச்சி , ஐரோப்பிய தொழிற்சங்கம் , ரோச் துணிகர நிதி ,

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

Excessive inflammation is a characteristic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, particularly in patients that are hospitalized with coronavirus disease 2019 (COVID-19). Here, Hoepel et al. investigated how human antibodies specific to SARS-CoV-2 spike protein may contribute to exacerbated inflammation. The authors found that spike protein–specific antibodies from patients with COVID-19 who were hospitalized had altered glycosylation, with an enrichment in low-fucosylated antibodies. These antibodies were able to activate human macrophages in vitro to secrete proinflammatory cytokines. Thus, altered antibody glycosylation may contribute to disease severity in COVID-19.

Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show ....

Noord Holland , United States , Miltenyi Biotec , U Cytech Biosciences , Melinda Gates Foundation , Dutch Federation Of University Medical Centers , Innovative Medicines Initiative , Amsterdam Cardiovascular Sciences , Agilent Technologies , Dutch Heart Foundation , Netherlands Organization For Health Research , European Union , Graphpad Software , Discovery Workbench Software , European Union Horizon , Proinflammatory Panel , European Commission , Vrije Universiteit Medical Center , Transatlantic Network Grant , Ethical Committee , Netherlands Cardiovascular Research Initiative , Netherlands Heart Foundation , Sanquin Blood Supply Foundation , Royal Netherlands Academy Of Sciences , Chemokine Panel , Biomarker Group ,

Mauna Kea Technologies Supports Clinical Research Evaluating the Use of Cellvizio on COVID-19 Patients with Respiratory Insufficiency

Mauna Kea Technologies Supports Clinical Research Evaluating the Use of Cellvizio on COVID-19 Patients with Respiratory Insufficiency
Regulatory News:
Mauna Kea Technologies (Euronext: MKEA) (Paris:MKEA) (OTCQX:MKEAY) inventor of Cellvizio, the multidisciplinary probe and needle-based confocal laser endomicroscopy (p/nCLE) platform, is supporting research to determine if Cellvizio can be effective in severe acute and/or long COVID-19 patients suffering from lingering respiratory complications. Mauna Kea Technologies is offering in-kind funding to researchers evaluating what role Cellvizio may play in the care management of COVID-19 patients, by assessing lung fibrosis and microvascularization changes, and alveolar and capillary morphology damages; symptoms observed in severe acute and/or long COVID-19 patients with mild to severe respiratory infections. Interested clinical teams can submit their projects to this website: www.landing.maunakeatech.com/covid19. ....

United States , France General , Noord Holland , Robertl Gershon , Jouket Annema , Marcus Schultz , Lieuwe Bos , Thomas Grojean , Olesyav Danilevskaya , Jouke Annema , Kirstena Mooij Kalverda , Mike Piccinino , Peter Bonta , Research Clinical Center , Malanip Health Consequences , French Financial Markets Authority Autorit , Amsterdam University Medical Center , Measure Acute , Long Term Pulmonary , Kea Technologies , Chief Executive Officer , Mauna Kea , Pulmonary Endoscopy , Netherlands Trial Registry , Professor Annema , Federal Research Clinical Center ,

Perspective of patients with autoimmune diseases on COVID-19 vaccination

Perspective of patients with autoimmune diseases on COVID-19 vaccination
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Noord Holland , Merck Serono , Smith Kline , Bayer Schering Pharma , Amsterdam Rheumatology Immunology Center , Biogen Idec , Amsterdam Multiple Sclerosis Center , Elsevier Ltd , Netherlands Trial Register , Between April , Amsterdam Rheumatology , Immunology Center , Rev Rheumatol , Rheum Dis , Glaxo Smith Kline , நூற்த் ஹாலண்ட் , மெர்க் செரோனோ , ஸ்மித் க்லைன் , பேயர் ஶரிஂக் பார்மா , பயோஜென் ஐடெக் , நெதர்லாந்து சோதனை பதிவு , இடையில் ஏப்ரல் , ஆம்ஸ்டர்டாம் வாத நோய் , நோயெதிர்ப்பு மையம் , வாதம் திஸ் , கிளாக்சோ ஸ்மித் க்லைன் ,