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Mixed Results with Refined Treatment Strategies for Rheumatic Diseases


May 5, 2021
Therapeutic drug monitoring, half-dosing may not be ready for prime-time
Therapeutic drug monitoring (TDM) for patients with immune-mediated inflammatory diseases did not lead to better clinical remission rates, while routine dose reduction of anti-rheumatic drugs for patients with rheumatoid arthritis (RA) in remission offered modest benefits, according to two Norwegian trials.
In the NOR-DRUM Part A trial, clinical remission at week 30 was achieved in 50.5% of 198 patients with TDM versus 53% of 200 patients in the standard therapy group, for an adjusted difference of 1.5% (95% CI −8.2% to 11.1%,
P=0.78), reported Silje Watterdal Syversen, MD, PhD, of Diakonhjemmet Hospital in Oslo, and co-authors.
In the ARCTIC REWIND trial, disease flare occurred in 25% of 77 patients in the half-dose conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) group versus 6% in the stable-dose csDMARD group for a risk difference of 18% (95% CI 7% ....

Silje Watterdal Syversen , Novartis Norge , Daiichi Sankyo , Eli Lilly , Infliximab Remicade , Siri Lillegraven , Shalmali Pal , Orion Pharma , Jeffreyr Curtis , Norwegian Regional Health Authorities , Boehringer Ingelheim , Thermo Fisher , University Of Alabama At Birmingham , South Eastern Norway Regional Health Authority , South Eastern Norway Regional Health Authorities , Research Council Of Norway , Diakonhjemmet Hospital , Contributing Writer , Norwegian Regional Health , Galderma Nordic , Bristol Myers Squibb , Merck Sharp , Research Council , South Eastern Norway Regional Health , Eisai Galapagos , தய்ச்சி சாங்கியோ ,

Maternal Chronic Conditions Predict Cerebral Palsy in Offspring

Maternal Chronic Conditions Predict Cerebral Palsy in Offspring
medscape.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medscape.com Daily Mail and Mail on Sunday newspapers.

United Kingdom , South Australia , Alastair Maclennan , Sandra Julsen Hollung , Norwegian Regional Health Authorities , National Institutes Of Health , Australian Collaborative Cerebral Palsy Research Group , Royal College Of Obstetricians , Vestfold Hospital , National Insurance Scheme , University Of Adelaide Australia , University Of Bergen Norway , Norwegian Patient Registry , National Insurance , Medical Birth Registry , Cerebral Palsy Registry , Vestfold Hospital Trust , Royal College , Professor Alastair Maclennan , National Institutes , Western Norwegian Regional Health , ஒன்றுபட்டது கிஂக்டம் , தெற்கு ஆஸ்திரேலியா , அலெஸ்டர் மேக்லென்னன் , நோர்வே பிராந்திய ஆரோக்கியம் அதிகாரிகள் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் ,