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Cannabis compound inhibits SARS-CoV-2 replication in human lung cells

Cannabis compound inhibits SARS-CoV-2 replication in human lung cells
Researchers in the United States have conducted a study showing that a cannabis plant compound inhibited infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human lung cells.
SARS-CoV-2 is the agent responsible for the coronavirus disease 2019 (COVID-19) pandemic that continues to sweep the globe posing a threat to global public health and the worldwide economy.
Marsha Rosner from the University of Chicago in Illinois and colleagues found that cannabidiol (CBD) and its metabolite 7-OH-CBD potently blocked SARS-CoV-2 replication in lung epithelial cells.
The CBD inhibited viral gene expression and reversed many of the effects the virus has on host gene transcription. ....

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Kronos Bio to Present Pre-Clinical Data at the AACR Virtual Annual Meeting 2021 for KB-0742, an Oral CDK9 Inhibitor Targeting MYC-amplified Cancers

Kronos Bio to Present Pre-Clinical Data at the AACR Virtual Annual Meeting 2021 for KB-0742, an Oral CDK9 Inhibitor Targeting MYC-amplified Cancers
yahoo.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from yahoo.com Daily Mail and Mail on Sunday newspapers.

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Scientists develop RNA-based therapeutic strategy for Charcot-Marie Tooth disease

Scientists develop RNA-based therapeutic strategy for Charcot-Marie Tooth disease
Charcot-Marie Tooth disease is the most common hereditary neurological disease in the world. It affects the peripheral nerves and causes progressive paralysis of the legs and hands.
No treatment is currently available to fight this disease, which is due to the overexpression of a specific protein. Scientists from the CNRS, INSERM, the AP-HP and the Paris-Saclay and Paris universities have developed a therapy based on degrading the coding RNA for this protein in mice. Their work is patented and was published on 9 March 2021 in
Communications Biology.
In molecular biology, transcription is when a DNA molecule is copied to make an RNA molecule. This RNA molecule is then translated into a protein, which can perform different functions within the body s cells. When a specific protein called PMP22 is made twice as much as normal, it causes type 1A of genetic Charcot-Marie Tooth disease t ....

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Apoptosis is an important mediator of pathogenesis in animal coronavirus infection

Apoptosis is an important mediator of pathogenesis in animal coronavirus infection
Apoptosis is a form of programmed cell death, which occurs in cells that are irreparably damaged or in cells infected by some viruses. This mechanism is extremely important in limiting a virus’s replication and its spread to other neighboring cells.
A new paper in the journal
Lifepresents an early review of the viral factors involved in initiating and effecting apoptosis within infected cells.
Colorized scanning electron micrograph of an apoptotic cell (blue) infected with SARS-COV-2 virus particles (red), isolated from a patient sample. Image captured at the NIAID Integrated Research Facility (IRF) in Fort Detrick, Maryland. Image Credit: NIAID / Flickr ....

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Researchers reprogram glial cells into new neurons to heal spinal cord injury

Researchers reprogram glial cells into new neurons to heal spinal cord injury
Researchers at Indiana University School of Medicine have successfully reprogrammed a glial cell type in the central nervous system into new neurons to promote recovery after spinal cord injury revealing an untapped potential to leverage the cell for regenerative medicine.
The group of investigators published their findings on March 5 in
Cell Stem Cell. This is the first time scientists have reported modifying NG2 glia a type of supporting cell in the central nervous system into functional neurons after spinal cord injury, said Wei Wu, Ph.D., a research associate in neurological surgery at IU School of Medicine and co-first author of the paper. ....

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