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NK cells combined with bispecific antibody display potent anti-tumor activity against lymphoma cells


NK cells combined with bispecific antibody display potent anti-tumor activity against lymphoma cells
Cytokine-activated natural killer (NK) cells derived from donated umbilical cord blood, combined with an investigational bispecific antibody targeting CD16a and CD30 known as AFM13, displayed potent anti-tumor activity against CD30+ lymphoma cells, according to a new preclinical study from researchers at The University of Texas MD Anderson Cancer Center.
The findings were published today in Clinical Cancer Research, a journal of the American Association for Cancer Research. These results led to the launch of a Phase I clinical trial to evaluate the combination of cord blood-derived NK cells (cbNK cells) with AFM13 as an experimental cell-based immunotherapy in patients with CD30+ lymphoma. ....

United States , Katy Rezvani , Emily Henderson , American Association For Cancer Research , University Of Texas Md Anderson Cancer Center , Md Anderson Cord Blood Bank , Clinical Cancer Research , American Association , Stem Cell Transplantation , Cord Blood Bank , Cancer Research , Bispecific Antibody , Clinical Trial , Umbilical Cord , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , அமெரிக்கன் சங்கம் க்கு புற்றுநோய் ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , மருத்துவ புற்றுநோய் ஆராய்ச்சி , அமெரிக்கன் சங்கம் , தண்டு செல் மாற்று அறுவை சிகிச்சை , தண்டு இரத்தம் வங்கி , புற்றுநோய் ஆராய்ச்சி ,

NK cells with bispecific antibody show activity against lymphoma cells


Date Time
NK cells with bispecific antibody show activity against lymphoma cells
Cytokine-activated natural killer (NK) cells derived from donated umbilical cord blood, combined with an investigational bispecific antibody targeting CD16a and CD30 known as AFM13, displayed potent anti-tumor activity against CD30+ lymphoma cells, according to a new preclinical study from researchers at The University of Texas MD Anderson Cancer Center.
The findings were published today in Clinical Cancer Research, a journal of the American Association for Cancer Research. These results led to the launch of a Phase I clinical trial to evaluate the combination of cord blood-derived NK cells (cbNK cells) with AFM13 as an experimental cell-based immunotherapy in patients with CD30+ lymphoma. ....

United States , Katy Rezvani , Pinaki Banerjee , American Association For Cancer Research , University Of Texas Md Anderson Cancer Center , National Institute Of Health , National Cancer Institute , Md Anderson Cord Blood Bank , Clinical Cancer Research , American Association , Stem Cell Transplantation , Cord Blood Bank , Cancer Research , National Institute , Institutional Conflict , Pinterest Management , Md Anderson Cancer Center , University Of Texas , National Cancer Institute , Conflict Of Interest , Cancer Research , Clinical Trial , Umbilical Cord , Cell Therapies , ஒன்றுபட்டது மாநிலங்களில் , பினாக்கி பானர்ஜி ,

COVID-19 vaccines in patients with cancer


(doi:10.1001/jamaoncol.2021.1218)
Editor s Note: The article includes conflicts of interest disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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United States , Dimitriosp Kontoyiannis , University Of Texas Md Anderson Cancer Center , What The Viewpoint Says , Cancer Center , For The Media , ஒன்றுபட்டது மாநிலங்களில் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , என்ன தி பார்வை என்கிறார் , புற்றுநோய் மையம் , க்கு தி மீடியா ,

BioSpace Movers & Shakers, May 14


Published: May 13, 2021
By Alex Keown
Akouos, Inc. – Kathy Reape was named chief development officer of Boston-based Akouos. Reape most recently served as chief medical officer at Spark Therapeutics where she oversaw clinical development, pharmacovigilance, and medical affairs activities. Reape was a key member of the team responsible for the development and commercialization of Luxturna, the first FDA-approved in vivo gene therapy approved for an inherited retinal disease caused by mutations in both copies of the RPE65 gene. Prior to Spark, Reape was senior vice president of clinical development focusing on global brands research and development at Allergan and Actavis.
CARMAT – France-based CARMAT’s board of directors is reorganizing its governance and appointed three new directors. The company tapped Florent Battistella, David Coti and John B. Hernandez as directors. Battistella founded Nisima, a holding company, which holds stakes in various fi ....

United States , Quadrucept Bio , Vineet Agarwal , Janice Olson , Einaro Vik Mo , Kyle Chiang , Penrose Therapeutx , Eli Lilly , Paul Manning , Mann Muhsin , Priteshj Gandhi , Mike Stapley , Annie Partisano , Cokey Nguyen , Stephen Squinto , Carries Cox , Roger Stupp , Andrea Paul , Bristol Myers Squibb , Christine Coyn , Susan Foden , Monika Hegi , Neurocentrx Pharma , Tanya Lewis , Mike Burgess , Jennifer Wheler ,