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Study helps unravel why pregnant women develop heart failure similar to older patients


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PHILADELPHIA Researchers at Penn Medicine have identified more genetic mutations that strongly predispose younger, otherwise healthy women to peripartum cardiomyopathy (PPCM), a rare condition characterized by weakness of the heart muscle that begins sometime during the final month of pregnancy through five months after delivery. PPCM can cause severe heart failure and often leads to lifelong heart failure and even death. The study is published today in
Circulation.
PPCM affects women in one out of every 2,000 deliveries worldwide, with about a third of those women developing heart failure for life, and about five percent of them dying within a few years. Maternal mortality in the United States has doubled in the last 20 years, and PPCM is a leading cause of these deaths. Previously, the reasons behind why women developed PPCM remained a mystery until a 2016 study strongly suggested that some genetic mutations predispose women to the disease. ....

United States , Rahul Goli , Zoltanp Arany , Ruth Perelman School Of Medicine , National Institutes Of Health , University Of Pennsylvania , University Of California San Francisco , University Of Pennsylvania Health System , Perelman School Of Medicine , Penn Medicine , Samuel Bellet Professor , Perelman School , California San Francisco , National Institutes , Ruth Perelman School , Pennsylvania Health System , World Report , Health Care , Medicine Health , Health Care Systems Services , Health Professionals , Metabolism Metabolic Diseases , ஒன்றுபட்டது மாநிலங்களில் , ராகுல் கோலி , ரூத் பெரல்மேன் பள்ளி ஆஃப் மருந்து , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் ,

Second COVID-19 Vaccine Important for Those Who Have Not Had the Disease


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People who have recovered from COVID-19 had a robust antibody response after the first mRNA vaccine dose, but little immune benefit after the second dose, according to new research from the Penn Institute of Immunology. The findings, published today in Science Immunology, suggest only a single vaccine dose may be needed to produce a sufficient antibody response. The team found that those who did not have COVID-19—called COVID naïve—did not have a full immune response until after receiving their second vaccine dose, reinforcing the importance of completing the two recommended doses for achieving strong levels of immunity. ....

South Africa , South African , E John Wherry , Penn Institute Of Immunology , University Of Pennsylvania , University Of Pennsylvania Health System , Perelman School Of Medicine , Penn Institute , Science Immunology , Systems Pharmacology , Translational Therapeutics , Perelman School , Pennsylvania Health , ஏ ஜான் வேரீ , பென் நிறுவனம் ஆஃப் நோயெதிர்ப்பு , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா , பல்கலைக்கழகம் ஆஃப் பென்சில்வேனியா ஆரோக்கியம் அமைப்பு , பெரல்மேன் பள்ளி ஆஃப் மருந்து , பென் நிறுவனம் , அறிவியல் நோயெதிர்ப்பு , அமைப்புகள் மருந்தியல் , மொழிபெயர்ப்பு சிகிச்சை , பெரல்மேன் பள்ளி , பென்சில்வேனியா ஆரோக்கியம் ,

Penn study finds reassuring data on common heart valve procedure, MitraClip


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PHILADELPHIA A retrospective study led by researchers from Penn Medicine found that with MitraClip for treatment of secondary mitral regurgitation (MR), a heart disease associated with problems in the left ventricle, there was no negative effect of having a slightly smaller mitral valve opening as long as there was good reduction of the mitral regurgitation. The study is published today in
JACC: Cardiovascular Interventions.
This data is very reassuring for physicians who place MitraClips in patients with secondary mitral regurgitation. It demonstrates that the benefits of MR reduction in patients with heart failure were maintained even when mild-to-moderate mitral stenosis, which can be caused by a narrowing of the mitral valve, occurred after MitraClip, said lead author Howard C. Herrmann, MD, the John Winthrop Bryfogle Professor of Cardiovascular Diseases in the Perelman School of Medicine at the University of Pennsylvania and Health System Director fo ....

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