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SHREK proteins mediate broad spectrum antiviral host immunity, including against SARS-CoV-2

A new preprint posted to the bioRxiv server demonstrates that similar mucins and mucin-like proteins cannot only suppress HIV-1 infectivity via blockage of viral attachment to the host cells but can block infection by multiple enveloped viruses. ....

Liji Thomas , Rigidly Extended Killer , Sars Cov 2 , Coronavirus Disease Covid 19 , Hiv 1 , Progenitor Cells ,

Bleeding disorder linked to poor clinical outcomes in COVID-19 patients

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the pathogen responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. Approximately 20-55% of hospitalized COVID-19 patients are reported to have deranged hemostatic laboratory parameters, which suggests coagulopathy. ....

Fort Detrick , United States , New York , Pubmed Medline , Susha Cheriyedath , Research Facility , Bleeding Disorder , Corona Virus , Coronavirus Disease Covid 19 , Critical Care , D Dimer , Health Care , Intensive Care , Sars Cov 2 , Severe Acute Respiratory , Severe Acute Respiratory Syndrome , கோட்டை டெட்ரிக் , ஒன்றுபட்டது மாநிலங்களில் , புதியது யார்க் , ஆராய்ச்சி வசதி , இரத்தப்போக்கு கோளாறு , கொரோனா வைரஸ் , முக்கியமான பராமரிப்பு , எதிர் மின்னணு , ஆரோக்கியம் பராமரிப்பு , தீவிர பராமரிப்பு ,

Researchers investigate protein phosphatase to identify new treatments for cancer, other diseases

Researchers investigate protein phosphatase to identify new treatments for cancer, other diseases
The abundant presence of an enzyme known as low molecular weight protein tyrosine phosphatase (LMWPTP) in tumor cells has long been considered an indicator of cancer aggressiveness and metastatic potential. It is also known to perform important functions in cells under normal conditions, participating in both the proliferation process and the regulation of intracellular systems. Research continues on its role in cancer progression.
In Brazil, a group of researchers at the University of Campinas s In Vitro Bioassay and Signal Transduction Laboratory led by Professor Carmen Veríssima Ferreira-Halder are studying the possibility of inhibiting this protein phosphatase to create novel opportunities for monitoring and treatment of cancer and other diseases. ....

Erasmus Mc Moniek , Emanuella Maria Barreto Fonseca , Nunzio Bottini , Helon Guimar , Sousa Faria , Sheila Siqueira Andrade , Emily Henderson , University Of California San Diego , University Of Campinas In Vitro Bioassay , Molecular Life Sciences , Transduction Laboratory , University Of Campinas , Vice Rectorship For International Relations , Vitro Bioassay , Signal Transduction Laboratory , Professor Carmen Ver , Thematic Project , Professor Maikel Peppelenbosch , Erasmus University Medical Center , Alessandra Val , California San Diego , Executive Vice Rectorship , Stefano Piatto Clerici , Plateinnove Biotech , Moniek De Maat , Gwenny Fuhler ,