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Do purines influence cancer development?


Credit: Laura Alvarez, CeMM
Numerous disease development processes are linked to epigenetic modulation. One protein involved in the process of modulation and identified as an important cancer marker is BRD4. A recent study by the research group of Giulio Superti-Furga, Principal Investigator and Scientific Director at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, now shows that the supply of purines as well as the purine synthesis of a cell can influence BRD4 activity and thus play a role in the carcinogenesis process. The findings were published in
Nature Metabolism.
Chromatin is a central component of the cell nucleus. It refers to the complex of the approximately two-meter-long human DNA with proteins that organize it so that - depending on the cell type - certain genes are activated or deactivated. In order to be able to adapt to diverse situations and influences, cells read the information relevant to them from the DNA. If t ....

Johannesw Bigenzahn , Felix Kartnig , Sarah Grosche , Jung Mingg Lin , Ulrich Goldmann , Sandra Schick , Kai Chun Li , Daniela Reil , Stefan Kubicek , Vitaly Sedlyarov , Kristaps Klavins , Enrico Girardi , Ariel Bensimon , Sara Sdelci , Innovative Medicine Initiative , Traudl Engelhorn Foundation , Austrian Science Fund , Union Horizon , Austrian Academy Of Sciences , European Commission Marie , European Research Council , Cemm Research Center , University Of Zurich , University Of Vienna , Giulio Superti Furga , Principal Investigator ,

Dyadic International, Inc.: Dyadic to Present at ZAPI Stakeholders Virtual Meeting


Dyadic International, Inc.: Dyadic to Present at ZAPI Stakeholders Virtual Meeting
JUPITER, FL / ACCESSWIRE / February 3, 2021 / Dyadic International, Inc. ( Dyadic ) (NASDAQ:DYAI), a global biotechnology company focused on further improving and applying its proprietary C1 gene expression platform to accelerate development, lower production costs, and improve the performance of vaccines, drugs and other biological products at flexible commercial scales, today announced that Ronen Tchelet, PhD, Dyadic s Chief Scientific Officer, will make a presentation during the European Union Innovative Medicines Initiative (IMI) Zoonotic Anticipation Preparedness Initiative - ZAPI Stakeholders Virtual Web Meeting to be held on February 4th and 5th, 2020.
Dyadic s C1 gene expression platform has played an important role in the success of the ZAPI project , said Mark Emalfarb, Dyadic s CEO. Mr Emalfarb continued Our participation in the ZAPI project has led to several fully funded anima ....

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