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Lithium treats intellectual defects in mouse model of Bardet-Biedl Syndrome

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IMAGE: Image of cilia in a mouse brain using Scanning Electron Microscopy, imaged and processed by Calvin S. Carter.
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Credit: Calvin S. Carter
Mice with symptoms that mimic Bardet-Biedl Syndrome (BBS) have difficulty with learning and generating new neurons in the hippocampus. However, according to a new study by Thomas Pak, Calvin Carter, and Val Sheffield of the University of Iowa, published April 22nd in the journal
PLOS Genetics, these mental defects can be successfully treated with lithium.
BBS is a rare genetic disorder that causes intellectual disability, vision loss and obesity, and sometimes kidney problems and extra fingers and toes. It is one of several ciliopathies, which are diseases that stem from defective cilia tiny, finger-like projections on the surface of cells that play important roles in moving fluids, sensing the environment and signaling between cells. Pak, Carter, Sheffield and colleagues wanted to learn ....

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Researchers discover new way to monitor & prevent nerve cell deterioration after TBI

Researchers discover new way to monitor & prevent nerve cell deterioration after TBI
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

United States , Kyoo Shin , Roberta Bonomo , Andrewa Pieper , Case Western Reserve School Of Medicine , Brockman Foundation , Allen Initiative In Brain Health , Va Geriatric Research , Harrington Discovery Institute , Neuropathology Core Of Northwestern University , Neurosurgery Of Mcgovern Medical School , Neurotherapeutics Center At University Hospitals , University Hospitals , Morley Mather Chair , Translational Therapeutics Core , Cleveland Alzheimer , Disease Research Center , Clinical Care , Min Kyoo Shin , Associate Chief , Ohio Healthcare System , Case Western Reserve School , Case Western Reserve , Cleveland Clinic , Allen Initiative , Brain Health ,

SRC-3 is a novel regulator of human immune T regulatory cells

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A study led by researchers at Baylor College of Medicine reveals a novel role of the steroid receptor coactivator 3 (SRC-3/NCOA3), a protein crucial for steroid hormone function and a prognostic marker for aggressive human breast and other cancers.
The team discovered that SRC-3 also regulates human immune T regulatory cells (Tregs), which contribute to the regulation of the body s immunological activity by suppressing the function of other immune cells, including those involved in fighting cancer. The study, which appears in the journal
Scientific Reports, shows that Tregs whose SRC-3 function was eliminated failed to suppress the activity of other immune cells in the lab. The authors anticipate that their findings may help in the fight against cancer in the future by leading to new approaches to inhibit Tregs activity which consequently would release immune attack in tumors. ....

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SRC-3 is a novel regulator of human immune T regulatory cells

E-Mail
A study led by researchers at Baylor College of Medicine reveals a novel role of the steroid receptor coactivator 3 (SRC-3/NCOA3), a protein crucial for steroid hormone function and a prognostic marker for aggressive human breast and other cancers.
The team discovered that SRC-3 also regulates human immune T regulatory cells (Tregs), which contribute to the regulation of the body s immunological activity by suppressing the function of other immune cells, including those involved in fighting cancer. The study, which appears in the journal
Scientific Reports, shows that Tregs whose SRC-3 function was eliminated failed to suppress the activity of other immune cells in the lab. The authors anticipate that their findings may help in the fight against cancer in the future by leading to new approaches to inhibit Tregs activity which consequently would release immune attack in tumors. ....

Baylor College Of Medicine , United States , University Of Houston , Subhamoy Dasgupta , Prashi Jain , Neil Mckenna , Qin Feng , Bryan Nikolai , Bert Omalley , David Lonard , David Cardenas , Roswell Park Comprehensive Cancer Center , Brockman Foundation , Union Biometrica Biosorter , Baylor Danl Duncan Comprehensive Cancer Center , Research Institute Of Texas , Cancer Center Support Grant , Baylor College , Scientific Reports , Berto Malley , Danl Duncan Comprehensive Cancer Center , Danl Duncan Comprehensive Cancer , Brian York , Cancer Prevention , Research Institute , Facility Support Award ,

Iowa and Ohio team finds strategy to protect developing brain from prenatal stress in mice

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New research from the University of Iowa and University Hospitals Cleveland Medical Center demonstrates that offspring can be protected from the effects of prenatal stress by administering a neuroprotective compound during pregnancy.
Working in a mouse model, Rachel Schroeder, a student in the UI Interdisciplinary Graduate Program in Neuroscience, drew a connection between the work of her two mentors, Hanna Stevens, MD, PhD, UI associate professor of psychiatry and Ida P. Haller Chair of Child and Adolescent Psychiatry, and Andrew A. Pieper, MD, PhD, a former UI faculty member, now Morley-Mather Chair of Neuropsychiatry at Case Western Reserve University and Investigator and Director of the Neurotherapeutics Center at the Harrington Discovery Institute, University Hospitals Cleveland Medical Center. ....

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