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Scientists identify receptor in cells that could be key to preventing cancer drug-induced hearing loss


Scientists identify receptor in cells that could be key to preventing cancer drug-induced hearing loss
University of Alberta scientists have identified a receptor in cells that could be key to preventing permanent hearing loss in childhood cancer survivors who are being treated with the drug cisplatin. The researchers believe by inhibiting the receptor, they may be able to eliminate toxic side-effects from the drug that cause the hearing loss.
Cisplatin is an incredibly effective chemotherapeutic when it comes to treating solid tumors in children, contributing to an 80 per cent overall survival rate over five years, according to U of A researcher Amit Bhavsar, an assistant professor in the Department of Medical Microbiology & Immunology. The problem has always been with the side-effects. Nearly 100 per cent of patients who receive higher doses of cisplatin show some degree of permanent hearing loss. The ability to prevent this side-effect would dramatically improve the qua ....

Frederick West , Ted Allison , Amit Bhavsar , Emily Henderson , Department Of Medical Microbiology Immunology , University Of Alberta , Department Of Biological Sciences , Mental Health Institute , Children Health Research Institute , Cancer Research Institute Of Northern Alberta , Li Ka Shing Institute Of Virology , Medical Microbiology , Biological Sciences , Mental Health , Cancer Research Institute , Northern Alberta , Health Research Institute , ஃப்ரெடரிக் மேற்கு , டெட் அல்லிசன் , அமித் பாவ்சர் , எமிலி ஹென்டர்சன் , துறை ஆஃப் மருத்துவ நுண்ணுயிரியல் நோயெதிர்ப்பு , பல்கலைக்கழகம் ஆஃப் ஆல்பர்ட்டா , துறை ஆஃப் உயிரியல் அறிவியல் , மன ஆரோக்கியம் நிறுவனம் , குழந்தைகள் ஆரோக்கியம் ஆராய்ச்சி நிறுவனம் ,

Researchers pinpoint possible way to prevent permanent hearing loss caused by cancer drug


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IMAGE: University of Alberta researcher Amit Bhavsar is leading a team that has identified a receptor in cells that could be key to preventing permanent hearing loss in childhood cancer survivors.
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Credit: William Au
University of Alberta scientists have identified a receptor in cells that could be key to preventing permanent hearing loss in childhood cancer survivors who are being treated with the drug cisplatin. The researchers believe by inhibiting the receptor, they may be able to eliminate toxic side-effects from the drug that cause the hearing loss.
Cisplatin is an incredibly effective chemotherapeutic when it comes to treating solid tumours in children, contributing to an 80 per cent overall survival rate over five years, according to U of A researcher Amit Bhavsar, an assistant professor in the Department of Medical Microbiology & Immunology. The problem has always been with the side-effects. Nearly 100 per cent of patients w ....

Frederick West , Ted Allison , Amit Bhavsar , University Of Alberta , Department Of Biological Sciences , Mental Health Institute , Children Health Research Institute , Li Ka Shing Institute Of Virology , Canadian Institutes Of Health Research , Department Of Medical Microbiology Immunology , Stollery Children Hospital Foundation , Cancer Research Institute Of Northern Alberta , Medical Microbiology , Biological Sciences , Mental Health , Cancer Research Institute , Northern Alberta , Health Research Institute , Canadian Institutes , Health Research , Stollery Children , Hospital Foundation , ஃப்ரெடரிக் மேற்கு , டெட் அல்லிசன் , அமித் பாவ்சர் , பல்கலைக்கழகம் ஆஃப் ஆல்பர்ட்டா ,