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Elevation Oncology Announces the Presentation of New Preclinical Data in Pancreatic and Cholangiocarcinoma PDX Models on the Specific Inhibition of HER3 with Seribantumab to Block NRG1 Fusion Signaling

NRG1 gene fusion. The CRESTONE study is currently enrolling at sites across the United States.
Here we observed that NRG1 fusions activated HER3 and downstream signaling mediators such as AKT in a pancreatic cell line, said Igor Odintsov, MD, Research Fellow at MSK and lead author of the poster presentation. Treatment with seribantumab was able to inhibit phosphorylation of the activated HER3 and AKT in the same cell line, and subsequent treatment of an
APP-NRG1 fusion-positive pancreatic PDX model with seribantumab robustly inhibited tumor growth at clinically achievable doses.
Regressions were observed in all mice treated with 10 mg/kg BIW seribantumab, equivalent to a clinical dose of 2.6 g seribantumab in humans by allometric scaling. As in prior analysis in lung and ovarian ....

United States , Shawnm Leland , David Rosen , Igor Odintsov , Marc Ladanyi , Clinical Cancer Research , Elevation Oncology , Memorial Sloan Kettering , American Association , Cancer Research Virtual Annual Meeting , Research Fellow , Chief Executive Officer , ஒன்றுபட்டது மாநிலங்களில் , டேவிட் ரோஸன் , மருத்துவ புற்றுநோய் ஆராய்ச்சி , உயரம் புற்றுநோயியல் , நினைவகம் ஸ்லோன் கெட்டரிங் , அமெரிக்கன் சங்கம் , புற்றுநோய் ஆராய்ச்சி மெய்நிகர் ஆண்டு சந்தித்தல் , ஆராய்ச்சி சக , தலைமை நிர்வாகி அதிகாரி ,

MediGene AG (via Public) / Identification of ten novel tumor-specific antigens immunogenic for T cells

Identification of ten novel tumor-specific antigens immunogenic for T cells
Planegg/Martinsried and Montréal - 10 April 2021. Medigene AG (Medigene, FSE: MDG1, Prime Standard), a clinical stage immuno-oncology company focusing on the development of T cell immunotherapies, today presents the screening and identification of novel immunogenic tumor-specific antigens (TSAs) derived from non-coding regions of the human genome at the American Association for Cancer Research Virtual Annual Meeting (AACR) 2021. The poster can be found on Medigene s website: https://www.medigene.com/technologies/abstracts
Significant efforts are being dedicated worldwide to identifying novel TSAs as targets for cancer immunotherapy. In this respect, not only known proteins but also non-coding genetic regions of cells are studied as sources of peptides that can be presented by HLA molecules at the surface of tumor cells and be recognized by T cell receptors (TCRs). Such TSAs can provide new targets ....

United States , Gary Waanders , Steven Klein , Dolores Schendel , Anna Niedl , Planegg Martinsried , Mary Ann Chang , Desbois Mackenzie , Centre Of Excellence , Cytovant Sciences Hk Ltd , Institute For Research , Communications Advisor , Business Development , Prime Standard , American Association , Cancer Research Virtual Annual Meeting , Chief Executive Officer , Chief Scientific Officer , Cytovant Sciences , ஒன்றுபட்டது மாநிலங்களில் , ஸ்டீவன் க்ளீன் , டோலோரஸ் திட்டமிடல் , மேரி ஆண்டு சாங் , மையம் ஆஃப் சிறப்பானது , நிறுவனம் க்கு ஆராய்ச்சி , வணிக வளர்ச்சி ,

Clovis Oncology Highlights Rubraca® (rucaparib) Clinical Data at AACR Virtual Annual Meeting 2021

Press release content from Business Wire. The AP news staff was not involved in its creation.
Clovis Oncology Highlights Rubraca® (rucaparib) Clinical Data at AACR Virtual Annual Meeting 2021
April 10, 2021 GMT
BOULDER, Colo. (BUSINESS WIRE) Apr 10, 2021
Clovis Oncology, Inc. (NASDAQ: CLVS) announced that Phase 1 clinical data from studies exploring Rubraca in combination with Xtandi for the treatment of advanced prostate cancer (RAMP) and Rubraca monotherapy in advanced solid tumors in Japanese patients (RUCA-J) will be presented during week one of the American Association for Cancer Research Virtual Annual Meeting (AACR), taking place April 10-15, 2021.
“We remain committed to understanding how Rubraca may benefit patients with cancer, and the data presented at AACR further enhance our understanding in different patient populations and solid tumor types,” said Patrick J. Mahaffy, President and CEO of Clovis Oncology. “The Phase 1b RAMP data for the co ....

United States , Arpit Rao , Patrickj Mahaffy , Kenji Tamura , Anna Sussman , Lisa Guiterman , Breanna Burkart , National Cancer Center Hospital , Clovis Oncology Inc , National Clinical Trials Network , National Cancer Institute , Alliance For Clinical Trials In Oncology , Alliance For Clinical , Community Research Oncology Program , Exchange Commission , Clinical Research , University Of Minnesota , American Association , Cancer Research Virtual Annual Meeting , Clinical Oncology Sponsored , Genomic Characteristics , Metastatic Castration Resistant Prostate Cancer , Japanese Patients , Previously Treated Advanced Solid , Phasei Clinical , Acute Myeloid Leukemia ,

Aptevo Therapeutics to Present at the American Association for Cancer Research Virtual Annual Meeting

Aptevo Therapeutics to Present at the American Association for Cancer Research Virtual Annual Meeting
SEATTLE, WA
/ ACCESSWIRE / April 9, 2021 / Aptevo Therapeutics Inc. (NASDAQ:APVO), a clinical-stage biotechnology company focused on developing novel immuno-oncology therapeutics based on its proprietary ADAPTIR
TM and ADAPTIR-FLEX
TM platform technologies, today announced that it will present two new posters at the American Association for Cancer Research Virtual Annual Meeting, to be held in two virtual sessions - Saturday, April 10
th to Thursday, April 15
th, 2021 and Monday, May 17
th to Friday, May 21
st, 2021.
Title: APVO603:
A Dual 4-1BB and OX40 bispecific approach utilizing ADAPTIR technology designed to deliver a conditional T cell/NK response against solid tumors ....

United States , Exchange Commission , Aptevo Therapeutics Inc , Aptevo Therapeutics , American Association , Cancer Research Virtual Annual Meeting , Poster Presentations , Virtual Poster Hall , Monday June , Private Securities Litigation Reform Act , Annual Report , ஒன்றுபட்டது மாநிலங்களில் , பரிமாற்றம் தரகு , அமெரிக்கன் சங்கம் , புற்றுநோய் ஆராய்ச்சி மெய்நிகர் ஆண்டு சந்தித்தல் , போஸ்டர் ப்ரெஸெஂடேஶந்ஸ் , மெய்நிகர் போஸ்டர் மண்டபம் , திங்கட்கிழமை ஜூன் , ப்ரைவேட் பத்திரங்கள் வழக்கு சீர்திருத்தம் நாடகம் , ஆண்டு அறிக்கை ,

Aptevo Therapeutics to Present at the American Association for Cancer Research Virtual Annual Meeting

Aptevo Therapeutics to Present at the American Association for Cancer Research Virtual Annual Meeting
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United States , Exchange Commission , Aptevo Therapeutics Inc , Aptevo Therapeutics , American Association , Cancer Research Virtual Annual Meeting , Poster Presentations , Virtual Poster Hall , Monday June , Private Securities Litigation Reform Act , Annual Report , ஒன்றுபட்டது மாநிலங்களில் , பரிமாற்றம் தரகு , அமெரிக்கன் சங்கம் , புற்றுநோய் ஆராய்ச்சி மெய்நிகர் ஆண்டு சந்தித்தல் , போஸ்டர் ப்ரெஸெஂடேஶந்ஸ் , மெய்நிகர் போஸ்டர் மண்டபம் , திங்கட்கிழமை ஜூன் , ப்ரைவேட் பத்திரங்கள் வழக்கு சீர்திருத்தம் நாடகம் , ஆண்டு அறிக்கை ,