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OMRF adds new cancer researcher

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United States , Jacob Kirkland , Oklahoma Medical Research Foundation , Cancer Biology Research Program , Stanford University , Cell Cycle , Cancer Biology Research , ஒன்றுபட்டது மாநிலங்களில் , ஜாகோப் கர்க்‌ல்யாஂட் , ஓக்லஹோமா மருத்துவ ஆராய்ச்சி அடித்தளம் , புற்றுநோய் உயிரியல் ஆராய்ச்சி ப்ரோக்ர்யாம் , ஸ்டான்போர்ட் பல்கலைக்கழகம் , செல் மிதிவண்டி , புற்றுநோய் உயிரியல் ஆராய்ச்சி ,

Innovative breakthrough promises to diagnose DNA rearrangement mutations

Innovative breakthrough promises to diagnose DNA rearrangement mutations
Doctors are increasingly using genetic signatures to diagnose diseases and determine the best course of care, but using DNA sequencing and other techniques to detect genomic rearrangements remains costly or limited in capabilities.
However, an innovative breakthrough developed by researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Department of Physics promises to diagnose DNA rearrangement mutations at a fraction of the cost with improved accuracy.
Led by VCU physicist Jason Reed, Ph.D., the team developed a technique that combines a process called digital polymerase chain reaction (dPCR) with high-speed atomic force microscopy (HSAFM) to create an image with such nanoscale resolution that users can measure differences in the lengths of genes in a DNA sequence. These variations in gene length, known as polymorphisms, can be key to accurately diagnosing many forms of c ....

United States , Alden Chesney , Jason Reed , Amir Toor , Emily Henderson , School Of Medicine , College Of Humanities , Virginia Commonwealth University Massey Cancer Center , American Society Of Hematology , Department Of Pathology , Association Of Molecular Pathology , Professor In Department Of Physics , Department Of Physics , Member Of Cancer Biology Research Program , Massey Cancer Center , Molecular Pathology , American Society , Cancer Center , Cancer Biology Research Program , Associate Professor , Virginia Commonwealth , Developmental Therapeutics , Dna Sequencing , Atomic Force Microscopy , Polymerase Chain Reaction , ஒன்றுபட்டது மாநிலங்களில் ,

VCU technology can turn DNA sequencing on its head for diagnosing certain DNA mutations

VCU technology can turn DNA sequencing on its head for diagnosing certain DNA mutations
News Highlights: VCU technology can turn DNA sequencing on its head for diagnosing certain DNA mutations
PICTURE: From left to right, postdoctoral researcher Andrey Mikheykin, Ph.D., Jason Reed, Ph.D., and postdoctoral fellow Sean Koebley, Ph.D., collaborated on the study. view more
Credit: John Wallace, VCU Massey Cancer Center
Physicians are increasingly using genetic signatures to diagnose diseases and determine the best care, but the use of DNA sequencing and other techniques to detect genomic rearrangements remains expensive or limited in scope. However, an innovative breakthrough developed by researchers at Virginia Commonwealth University Massey Cancer Center and the VCU Department of Physics promises to diagnose DNA rearrangement mutations at a fraction of the cost with improved accuracy. ....

United States , Virginia Commonwealth University Massey Cancer Center , Loren Picco , Andrey Mikheikin , John Wallace , Kevin Leslie , Jason Reed , Joshua Lehman , Catherine Roberts , Xiaojie Zhang , Andrey Mikheykin , Alden Chesney , Taha Al Juhaishi , Amir Toor , Sean Koebley , Wendy Mcconnell , Department Of Internal Medicine , School Of Medicine , National Institutes Of Health , College Of Humanities , American Society Of Hematology , Cancer Biology Research Program , Commonwealth Health Research Board Of Virginia , Department Of Pathology , Department Of Physics , Association Of Molecular Pathology ,

Researchers identify new immune cell that acts as major driver of breast cancer growth

Researchers identify new immune cell that acts as major driver of breast cancer growth
Breast cancer is the most common cancer in women worldwide, but many immunotherapies have had limited success in treating aggressive forms of the disease.
A deeper understanding of the immunobiology of breast cancer is critical to the success in harnessing immunotherapeutic approaches to improve breast cancer survival, said Paula Bos, Ph.D., member of the Cancer Biology research program at VCU Massey Cancer Center and assistant professor in the Department of Pathology at the VCU School of Medicine.
New research findings from Bos, published in
Cell Reports, identified a type of immune cell that acts as a major driver of breast cancer growth by preventing the accumulation of a specific protein that induces anti-tumor responses. This new knowledge could be utilized for the development of novel immunotherapeutic approaches to treat the disease. ....

Paula Bos , Emily Henderson , Member Of The Cancer Biology Research Program , School Of Medicine , Department Of Pathology , Virginia Commonwealth University School Of Medicine , Massey Cancer Center , Cancer Biology , Cancer Center , Cell Reports , Cancer Biology Research Program , Assistant Professor , Virginia Commonwealth University School , பால போஸ் , எமிலி ஹென்டர்சன் , உறுப்பினர் ஆஃப் தி புற்றுநோய் உயிரியல் ஆராய்ச்சி ப்ரோக்ர்யாம் , பள்ளி ஆஃப் மருந்து , துறை ஆஃப் நோயியல் , வர்ஜீனியா காமன்வெல்த் பல்கலைக்கழகம் பள்ளி ஆஃப் மருந்து , மஸ்ஸி புற்றுநோய் மையம் , புற்றுநோய் உயிரியல் , புற்றுநோய் மையம் , செல் அறிக்கைகள் , புற்றுநோய் உயிரியல் ஆராய்ச்சி ப்ரோக்ர்யாம் , உதவியாளர் ப்ரொஃபெஸர் , வர்ஜீனியா காமன்வெல்த் பல்கலைக்கழகம் பள்ளி ,