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Study reveals structure of key receptors involved in memory and learning


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Scientists have for the first time revealed the structure surrounding important receptors in the brain s hippocampus, the seat of memory and learning.
The study, carried out at Oregon Health & Science University, published today in the journal
Nature.
The new study focuses on the organization and function of glutamate receptors, a type of neurotransmitter receptor involved in sensing signals between nerve cells in the hippocampus region of the brain. The study reveals the molecular structure of three major complexes of glutamate receptors in the hippocampus.
The findings may be immediately useful in drug development for conditions such as epilepsy, said senior author Eric Gouaux, Ph.D., senior scientist in the OHSU Vollum Institute, Jennifer and Bernard Lacroute Endowed Chair in Neuroscience Research and an Investigator with the Howard Hughes Medical Institute. ....

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Researchers discover new class of cancer fighting compounds


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Researchers discover new class of cancer fighting compounds
CORVALLIS, Ore. – A team of Oregon State University scientists has discovered a new class of anti-cancer compounds that effectively kill liver and breast cancer cells.
The findings, recently published in the journal Apoptosis, describe the discovery and characterization of compounds, designated as Select Modulators of AhR-regulated Transcription (SMAhRTs).
Edmond Francis O’Donnell III and a team of OSU researchers conducted the research in the laboratory of Siva Kolluri, a professor of cancer research at Oregon State. They also identified the aryl hydrocarbon receptor (AhR) as a new molecular target for development of cancer therapeutics. ....

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