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Pinpointing how cancer cells turn aggressive

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IMAGE: Researchers from the University of Pennsylvania used a novel technique based on the CRIPSR-Cas9 system to precisely track the lineage of cancer cells. They found that that one clone (represented.
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Credit: University of Pennsylvania
It s often cancer s spread, not the original tumor, that poses the disease s most deadly risk.
And yet metastasis is one of the most poorly understood aspects of cancer biology, says Kamen Simeonov, an M.D.-Ph.D. student at the University of Pennsylvania Perelman School of Medicine.
In a new study, a team led by Simeonov and School of Veterinary Medicine professor Christopher Lengner has made strides toward deepening that understanding by tracking the development of metastatic cells. Their work used a mouse model of pancreatic cancer and cutting-edge techniques to trace the lineage and gene expression patterns of individual cancer cells. They found a spectrum of aggression in the cells that a ....

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Caffeine in pregnancy can have lasting effect on fetal brain

Caffeine consumed during pregnancy can change important brain pathways that could lead to behavioral problems later in life, according to new research.
Researchers analyzed thousands of brain scans of nine and 10-year-olds, and revealed changes in the brain structure of children exposed to caffeine in utero.
“I suppose the outcome of this study will be a recommendation that any caffeine during pregnancy is probably not such a good idea.”
“These are sort of small effects and it’s not causing horrendous psychiatric conditions, but it is causing minimal but noticeable behavioral issues that should make us consider long term effects of caffeine intake during pregnancy,” says John Foxe, director of the Del Monte Institute for Neuroscience, and principal investigator of the Adolescent Brain Cognitive Development or ABCD Study at the University of Rochester. ....

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Obituary: Luis Glaser, former head of biological chemistry department, 88 – Washington University School of Medicine in St. Louis

Glaser
Luis Glaser, PhD, a beloved mentor and former head of the then-Department of Biological Chemistry at Washington University School of Medicine in St. Louis, died Dec. 23, 2020, in Miami after a long illness. He was 88.
Also a director of the university’s Division of Biology & Biomedical Sciences, Glaser spent the latter years of his career, from 1986 to 2005, as executive vice president and provost at the University of Miami.
At Washington University, where he earned his PhD in biochemistry, Glaser studied in the laboratory of Nobel laureates Carl and Gerty Cori. He joined the faculty as an instructor in 1956 and rose to head of the biological chemistry department, precursor to the Department of Biochemistry and Molecular Biophysics; he held that position from 1975 to 1986. He also became director of the Division of Biology & Biomedical Sciences, in 1980. He retired from Washington University in 1986 but remained affiliated with the School of Medicine as an adj ....

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