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Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study

Research Article
Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study
Guillaume Butler-Laporte ,
Contributed equally to this work with:
Guillaume Butler-Laporte,
Tomoko Nakanishi
Roles
Conceptualization,
Data curation,
Formal analysis,
Investigation,
Methodology,
Software,
Validation,
Visualization,
Writing – original draft,
Writing – review & editing
Affiliations
Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Québec, Canada,
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal, Québec, Canada
Contributed equally to this work with:
Guillaume Butler-Laporte,
Tomoko Nakanishi
Roles
Conceptualization,
Data curation,
Formal analysis,
....

United Kingdom , City Of , King College London , International Classification Of Diseases , Clinical Research Facility , Lady Davis Institute Of The Jewish , Ministry Of Health , Canadian Foundation For Innovation , Imperial College London , European Union , Public Health Agency Of Canada , Host Genetics Initiative , Research Council , Canada Excellence Research , Program For Young Researchers , Canadian Institutes Of Health Research , National Institute For Health Research , Clinical Research Scholarship , Biomedical Research Centre , Cancer Research United Kingdom , United Kingdom Biobank , Genetics Initiative , Cosetta Minelli , Creative Commons Attribution License , Canadian Institutes , Health Research ,

Vitamin D may not provide protection from COVID-19 susceptibility or disease severity

E-Mail
Observational studies have suggested that increased vitamin D levels may protect against COVID-19. However, these studies were inconclusive and possibly subject to confounding. A study published in
PLOS Medicine by Guillaume Butler-Laporte and Tomoko Nakanishi at McGill University in Quebec, Canada, and colleagues suggests that genetic evidence does not support vitamin D as a protective measure against COVID-19.
The ability of vitamin D to protect against severe COVID-19 illness is of great interest to public health experts, but has limited supporting evidence. To assess the relationship between vitamin D levels and COVID-19 susceptibility and severity, researchers conducted a Mendelian randomization study using genetic variants strongly associated with increased vitamin D levels. The authors analyzed genetic variants of 4,134 individuals with COVID-19, and 1,284,876 without COVID-19, from 11 countries to determine whether genetic predisposition for higher vi ....

United Kingdom , City Of , Guillaume Butler Laporte , King College London , Clinical Research Facility , Lady Davis Institute Of The Jewish , Ministry Of Health , Research Article , Canadian Foundation For Innovation , European Union , Public Health Agency Of Canada , Research Council , Canada Excellence Research , Host Genetics Initiative , Program For Young Researchers , Tomoko Nakanishi At Mcgill University In Quebec , Canadian Institutes Of Health Research , Clinical Research Scholarship , National Institute For Health Research , Biomedical Research Centre , Cancer Research United Kingdom , Tomoko Nakanishi , Mcgill University , Canadian Institutes , Health Research , Lady Davis Institute ,