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Gut bacteria point to novel strategies for combating asthma, COVID-19


Jan 25, 2021 11:00am
Australian researchers found a protective effect of L-tyrosine and p-cresol sulfate in mouse asthma models as well as preclinical models of lung inflammation caused by COVID-19. (Pixabay)
One of the questions researchers have about the microbiome the population of bacteria that live in the gut is how it might be influenced by the immune system. A team of researchers from Monash University s Central Clinical School in Melbourne, Australia, set out to answer that question, and in the process found two molecules the scientists believe could offer new treatment strategies for asthma.
One of the molecules, L-tyrosine, is sold over the counter as a dietary supplement. So, the researchers plan to fast-track it into clinical trials. If it works, they believe it might also be used to treat acute respiratory distress syndrome (ARDS) in COVID-19 patients, they reported in the journal Nature Immunology. ....

South Australia , Benjamin Marsland , Monash University , Monash University Central Clinical School , Central Clinical School , Clinical Trials Summit , Premier Educational Event Focused , Decentralized Clinical , Mayo Clinic , தெற்கு ஆஸ்திரேலியா , மோனாஷ் பல்கலைக்கழகம் , மோனாஷ் பல்கலைக்கழகம் மைய மருத்துவ பள்ளி , மைய மருத்துவ பள்ளி , மருத்துவ சோதனைகள் உச்சிமாநாடு , ப்ரிமியர் கல்வி நிகழ்வு கவனம் , மயோ சிகிச்சையகம் ,

Evoq pens $240M Amgen pact for next-gen autoimmune meds


(Business Wire)
Amgen has penned a deal worth $240 million-plus with biotech Evoq Therapeutics as it looks to the future for autoimmune research.
Looking to bolster the success of its own autoimmune offerings in the form of Otezla, Enbrel and its growing biosimilar products, Amgen is seeking the next generation of therapies for this highly lucrative disease area.
To help with this, Amgen is tapping Michigan-based Evoq, a spinoff from the University of Michigan, and its early-stage preclinical program in autoimmune disease. Amgen will be on the hook for $240 million-plus, as well as sales royalties, although this wasn’t broken down and no upfront figure was cited. ....

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Tessera Therapeutics scores $230M to ramp up 'gene writing' tech to cure disease


Jan 12, 2021 8:45am
At its core, gene writing simply means writing short or long messages into the genome to treat disease, said Tessera CEO Geoffrey von Maltzahn, Ph.D. (Getty Images)
Geoffrey von Maltzahn, Ph.D.
(Flagship Pioneering)
Move over, gene editing. There’s a new kid on the block. Tessera Therapeutics is pioneering “gene writing,” a kind of genetic medicine it hopes will surmount the limitations of gene editing and gene therapy and investors have bet more than $230 million on the approach.
At its core, gene writing simply means writing short or long messages into the genome to treat disease, said Tessera CEO Geoffrey von Maltzahn, Ph.D. “What that allows is one to be able to cure or prevent a disease from ever happening by writing in the code of DNA, which of course drives the biology in every single cell in the body,” he said. Tessera is developing multiple ways to do it. ....

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