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Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins

Researchers identify human BCAS3 and C16orf70 as novel autophagic proteins
Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective autophagy process to eliminate damaged mitochondria. PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged mitochondria, then ubiquitin chains are recognized as signals for autophagy degradation. Dysfunction of mitophagy causes a decrease in mitochondrial quality with overproduction of ROS, and is linked to neurodegenerative diseases like Parkinson s disease. ....

Emily Henderson , Ubiquitin Project , Breast Carcinoma Amplified Sequence , Drug Discovery , Life Science , Neurodegenerative Diseases , Parkinson 39s Disease , எமிலி ஹென்டர்சன் , மார்பக புற்றுநோய் பெருக்கப்பட்டது வரிசை , மருந்து கண்டுபிடிப்பு , வாழ்க்கை அறிவியல் ,

BCAS3-C16orf70 complex is a new actor on the mammalian autophagic machinery

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IMAGE: The confocal microscopy image of cell induced mitophagy. Autophagic membranes engulf the damaged mitochondria. TOMM20 (blue) is mitochondrial outer membrane protein and WIPI2 (red) is well-known autophagy protein. BCAS3-C16orf70 (green).
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Credit: TMIMS
Autophagy is an intracellular degradation process of cytosolic materials and damaged organelles. Researchers at Ubiquitin Project of TMIMS have been studying the molecular mechanism of mitophagy, the selective autophagy process to eliminate damaged mitochondria. PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged mitochondria, then ubiquitin chains are recognized as signals for autophagy degradation. Dysfunction of mitophagy causes a decrease in mitochondrial quality with overproduction of ROS, and is linked to neurodegenerative diseases like Parkinson s disease. ....

Life Science Research , Tokushima University , Institute Of Advanced Medical Sciences , Research Programs , University Of Tokushima , Takeda Science Foundation , Chieko Iwanaga Fund For Parkinson Disease Research , National Institute Of Advanced Industrial Science , Ubiquitin Project , Breast Carcinoma Amplified Sequence , National Institute , Advanced Industrial Science , Chieko Iwanaga Fund , Disease Research , Joint Usage , Joint Research Programs , Advanced Medical Sciences , Platform Project , Supporting Drug Discovery , Supporting Innovative Drug Discovery , Molecular Biology , Medicine Health , Biomedical Environmental Chemical Engineering , வாழ்க்கை அறிவியல் ஆராய்ச்சி , டோக்குஷிமா பல்கலைக்கழகம் , ஆராய்ச்சி ப்ரோக்ர்யாம்ஸ் ,