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Basic cell health systems wear down in Huntington's disease, analysis shows | MIT News | Massachusetts Institute of Technology

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Researchers employed a software system called Geomic to integrate vast amounts of gene expression data from the brains of mice modeling Huntington s disease. By comparing multidimensional mathematical surfaces plotted from the data, they were able to gain new insights into how gene expression differs in the disease based on many dimensions such as time, cell type and the extent of mutation in the huntingtin gene.
Credits:
Image: Lucile Megret/Sorbonne Universite
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Using an innovative computational approach to analyze vast brain cell gene expression datasets, researchers at MIT and Sorbonne Université have found that Huntington’s disease may progress to advanced stages more because of a degradation of the cells’ health maintenance systems than because of increased damage from the disease pathology itself. ....

Myriam Heiman , Mary Wertz , Christian Neri , Barbara Gris , Thomas Vogt , Jasmin Cevost , Lucile Megret , Jeff Aaronson , Satish Nair , Jim Rosinski , William Yang , Hilary Wilkinson , Broad Institute , University Of California At Los Angeles , Department Of Brain , National Institutes Of Health , Cognitive Sciences , Picower Institute For , Sorbonne Centre National De La Recherche Scientifique , Sorbonne Universit , Picower Institute , Centre National De La Recherche Scientifique , Los Angeles , National Institutes , Picower Institute For Learning And Memory , Huntington Amp 039s Disease ,

James DiCarlo named director of the MIT Quest for Intelligence

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Photo: Justin Knight
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James DiCarlo, the Peter de Florez Professor of Neuroscience, has been appointed to the role of director of the MIT Quest for Intelligence. MIT Quest was launched in 2018 to discover the basis of natural intelligence, create new foundations for machine intelligence, and deliver new tools and technologies for humanity.
As director, DiCarlo will forge new collaborations with researchers within MIT and beyond to accelerate progress in understanding intelligence and developing the next generation of intelligence tools.
“We have discovered and developed surprising new connections between natural and artificial intelligence,” says DiCarlo, currently head of the Department of Brain and Cognitive Sciences (BCS). “The scientific understanding of natural intelligence, and advances in building artificial intelligence with positive real-world impact, are interlocked aspects of a unified, coll ....

Laura Schulz , Daniel Huttenlocher , Aude Oliva , James Dicarlo , Li Huei Tsai , Nergis Mavalvala , Rebecca Saxe , Nicholas Roy , Robert Desimone , Henry Ellis Warren , Johns Hopkins University , Artificial Intelligence Laboratory , Department Of Brain , Mcgovern Institute For Brain Research , Cognitive Sciences , School Of Science , Department Of Electrical Engineering , Picower Institute For , Schwarzman College Of Computing , Watson Ai Lab , Department Head Michale Fee , Baylor College Of Medicine , Peter De Florez Professor , Computer Science , Electrical Engineering , Mcgovern Institute ,

Brain waves guide us in spotlighting surprises

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Our ability to highlight surprises stems from a specific interplay of brain waves that suppress processing of predicted stimuli, such as the things we always see around the office, to pave the way for heightened processing of what s new, like a gift left on the desk one morning.
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If you open your office door one morning and there is a new package waiting on your desk, that’s what you will notice most in the otherwise unchanged room. A recent study by MIT and Boston University neuroscientists finds that the dynamic interplay of different brain wave frequencies, rather than dedicated circuitry, appears to govern the brain’s knack for highlighting what’s surprising and downplaying what’s predictable. ....

Nancy Kopell , Earl Miller , Mikael Lundqvist , Ayan Waite , Department Of Brain , Office Of Naval Research , National Institutes Of Mental Health , Proceedings Of The National Academy Sciences , Cognitive Sciences , Boston University , Picower Institute For , Picower Professor , National Academy , Picower Institute , William Fairfield Warren Distinguished Professor , National Institutes , Mental Health , Naval Research , Brain Waves , Brain Wave Frequencies , Alpha Waves , Beta Waves , Gamma Waves , Andre Bastos , Mit Brain And Cognitive Sciences , ஏர்ல் மில்லர் ,