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Molecule reduces inflammation in Alzheimer's models | MIT News | Massachusetts Institute of Technology

A new candidate drug reduced inflammation and improved memory in human cell cultures and Alzheimer’s mouse models. The work was co-led by the lab of Li-Huei Tsai at the Picower Institute for Learning and Memory. ....

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Study connects neural gene expression differences to functional distinctions

The Picower Institute for Learning and Memory found that the two closely related neuronal subtypes differed from each other in how they expressed more than 800 genes. By manipulating genes whose expression differed most prominently, the scientists were then able to show how they produced several of the observable differences between the cells. ....

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Sparse, small, but diverse neural connections help make perception reliable, efficient

MIT researchers report that thalamic inputs into superficial layers of the cortex are not only rare, but also surprisingly weak, and quite diverse in their distribution patterns. Despite this, they are reliable and efficient representatives of information in the aggregate, and their diversity is what underlies these advantages. ....

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Alzheimer's risk gene undermines insulation of brain's "wiring" | MIT News | Massachusetts Institute of Technology

MIT research shows that in people carrying the APOE4 risk variant, a key brain cell type mismanages cholesterol needed to insulate neurons properly another sign that APOE4 contributes to Alzheimer's disease by disrupting lipids in the brain. ....

Martin Kahn , Chih Yu Chen , Cristina Blanco Duque , Manolis Kellis , Michael Bula , Eric Orlund , Lea Rbibo , Audrey Effenberger , Shawn Davidson , William Ralvenius , Hansruedi Mathys , Nicolas Lavoie , Kristan Maner Smith , Liwang Liu , Ricardo Reyes , David Bennet , Li Huei Tsai , Emre Agbas , Joel Blanchard , Jose Davila Velderrain , Xueqiao Jiang , Ihab Jahhar , Sinai Icahn School Of Medicine , Gene Ludwig Family Foundation , Department Of Brain , Cure Alzheimer Fund ,

Are Covid-19 "comas" signs of a protective hibernation state? | MIT News | Massachusetts Institute of Technology

Observations of Covid-19 patients who have been slow to wake up after the end of sedation suggest that the brain may be adopting a previously unknown protective, hibernation-like state. ....

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