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Some Covid-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells. A new MIT study shows that different nanoparticles could be used for a potential Alzheimer’s disease (AD) therapy. In tests in multiple m
In mice and human cell cultures, MIT researchers showed that lipid nanoparticles can deliver a potential RNA therapy for inflammation in the brain, a prominent symptom in Alzheimer’s disease.
<p>In mice and human cell cultures, MIT researchers showed that novel nanoparticles can deliver a potential therapy for inflammation in the brain, a prominent symptom in Alzheimer’s disease</p>
New MIT research shows that human microglia with the R47H/+ mutation in the TREM2 protein exhibit several deficits related to Alzheimer’s pathology. Mutant microglia are prone to inflammation, yet are worse at responding to neuron injury and less able to clear harmful debris, including amyloid beta.
A new candidate drug reduced inflammation and improved memory in human cell cultures and Alzheimer’s mouse models. The work was co-led by the lab of Li-Huei Tsai at the Picower Institute for Learning and Memory.