How a mutation in microglia elevates Alzheimer's risk | MIT

New MIT research shows that human microglia with the R47H/+ mutation in the TREM2 protein exhibit several deficits related to Alzheimer’s pathology. Mutant microglia are prone to inflammation, yet are worse at responding to neuron injury and less able to clear harmful debris, including amyloid beta.

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Blerta Milo , Hannah Woolf , William Ralvenius , Li Huei Tsai , Rjay Penney , Chieh Pao , Vishnu Dileep , University Of Prince Edward Island , Renee Belfer Family Foundation , National Institutes Of Health , Human Frontier Science Program , Picower Institute For , Cure Alzheimer Fund , Picower Institute , Picower Professor , Prince Edward , Anjanet Loon , Oyku Cerit , Ping Chieh Pao , Cure Alzheimer , National Institutes , Mit Picower Institute For Learning And Memory , Alzheimer Amp 039s Disease , Microglia Alzheimers , 47h Mutation , Rem2 Protein , Amyloid Beta , Dementia , Kay Penney , Inflammation ,