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Underlying Mechanisms behind Hypoxia's Effect on the Brain Revealed

Researchers at Massachusetts General Hospital (MGH) identified a mechanism that protects the brain from the effects of hypoxia. ....

United States , Fumito Ichinose , Nature Communications , Critical Care Research , Anesthesia Center , Massachusetts General Hospital , Critical Care , ஒன்றுபட்டது மாநிலங்களில் , இயற்கை தகவல்தொடர்புகள் , முக்கியமான பராமரிப்பு ஆராய்ச்சி , மயக்க மருந்து மையம் , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை , முக்கியமான பராமரிப்பு ,

New Discovery Could Help Treat Strokes, Cardiac Arrest

Researchers at Massachusetts General Hospital (MGH) identified a mechanism that protects the brain from the effects of hypoxia, a potentially lethal deprivation of oxygen. ....

Fumito Ichinose , Nature Communications , Department Of Anesthesia , Critical Care Research , Anesthesia Center , Critical Care , Pain Medicine , Implantable Cardioverter Defibrillator , Eprivation Of Oxygen , Cardiac Arrest , Nature Communications , இயற்கை தகவல்தொடர்புகள் , துறை ஆஃப் மயக்க மருந்து , முக்கியமான பராமரிப்பு ஆராய்ச்சி , மயக்க மருந்து மையம் , முக்கியமான பராமரிப்பு , வலி மருந்து ,

Researchers identify mechanism that may lead to new therapies for strokes, brain injuries

Researchers identify mechanism that may lead to new therapies for strokes, brain injuries
In a surprising discovery, researchers at Massachusetts General Hospital (MGH) identified a mechanism that protects the brain from the effects of hypoxia, a potentially lethal deprivation of oxygen.
This serendipitous finding, which they report in
Nature Communications, could aid in the development of therapies for strokes, as well as brain injury that can result from cardiac arrest, among other conditions.
However, this study began with a very different objective, explains senior author Fumito Ichinose, MD, PhD, an attending physician in the Department of Anesthesia, Critical Care and Pain Medicine at MGH, and principal investigator in the Anesthesia Center for Critical Care Research. ....

United States , Fumito Ichinose , Emily Henderson , Nature Communications , Department Of Anesthesia , Critical Care Research , Anesthesia Center , Massachusetts General Hospital , Critical Care , Pain Medicine , Study Senior Author , Attending Physician , Massachusetts General , ஒன்றுபட்டது மாநிலங்களில் , எமிலி ஹென்டர்சன் , இயற்கை தகவல்தொடர்புகள் , துறை ஆஃப் மயக்க மருந்து , முக்கியமான பராமரிப்பு ஆராய்ச்சி , மயக்க மருந்து மையம் , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை , முக்கியமான பராமரிப்பு , வலி மருந்து , படிப்பு மூத்தவர் நூலாசிரியர் , கலந்துகொள்வது மருத்துவர் , மாசசூசெட்ஸ் ஜநரல் ,

Serendipitous discovery could lead to treatment for strokes, cardiac arrest

Lack of oxygen, which is harmful to the brain, causes hydrogen sulfide sewer gas to accumulate in the brain. The brains of lab animals repeatedly exposed to hydrogen sulfide became tolerant to the gas and lack of oxygen. Researchers identified the mechanism that induces this tolerance, which could lead to new treatments for brain injuries caused by oxygen deprivation. ....

United States , Eizo Marutani , Fumito Ichinose , Nature Communications , Harvard Medical School , National Science Foundation , Technology Agency , Japanese Ministry Of Education , Department Of Anesthesia , Critical Care Research , Japan Agency For Medical Research , Anesthesia Center , Blood Institute , National Heart , National Institute , Department Of Anesthesia Critical Care , National Institute Of Neurological Disorders , Massachusetts General Hospital , Critical Care , Pain Medicine , Anesthesia Critical Care , William Thomas Green Morton Professor , Japanese Ministry , Japan Science , Japan Agency , Medical Research ,

Two distinct types of COVID-19-associated acute respiratory distress syndrome identified

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BOSTON - Approximately one in four patients hospitalized for the acute respiratory distress syndrome (ARDS) associated with severe COVID-19 infections may have a distinct phenotype (disease presentation) or biochemical profile associated with organ dysfunction, blood-clotting abnormalities and greater risk of death than patients with other, seemingly similar forms of the disease, researchers at Massachusetts General Hospital (MGH) have found.
Among 263 patients admitted to intensive care units (ICUs) at MGH for respiratory failure due to severe COVID-19 infection, 70 (26.6%) had increased levels of biomarkers in the bloodstream indicating disordered blood clotting, higher inflammation, and organ dysfunction compared with the other patients, report Sylvia Ranjeva MD, PhD, and Lorenzo Berra, MD, investigators in the Department of Anesthesia, Critical Care and Pain Medicine, and their colleagues in that department and Pulmonary and Critical Care Medicine and Respira ....

United States , Lorenzo Berra , Evan Hodell , Mariel Mueller , C Corey Hardin , Riccardo Pinciroli , B Taylor Thompson , Department Of Anesthesia , Anesthesia Center , Harvard Medical School To Berra , Massachusetts General Hospital , Sylvia Ranjeva , Critical Care , Pain Medicine , Critical Care Medicine , Respiratory Care , Reginald Jenney Endowment Chair , Harvard Medical School , Lorenzo Berra Sundry Funds , Critical Care Research , Medicine Health , Critical Care Emergency Medicine , Immunology Allergies Asthma , Infectious Emerging Diseases , Pulmonary Respiratory Medicine , ஒன்றுபட்டது மாநிலங்களில் ,