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Variability in Cognitive Decline Raises Questions About Alzheimer's Trials


Jun 9, 2021
Simulation reflected a trial with no treatment effect
Variability in individual cognitive trajectories may be why cognitive results in most Alzheimer’s disease (AD) trials fell within the level of random differences that occur when no treatment effect is expected, a simulation study showed.
“Our simulation reflects a clinical trial in which there is no real treatment effect, and so the 95% range of group differences between our ’placebo’ and ’treatment’ groups reflect the possible range of scores that can be expected when there is no treatment effect,” wrote Roos Jutten, PhD, of Amsterdam UMC in the Netherlands, and co-authors, in ....

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Vivoryon Therapeutics N.V.: Vivoryon Therapeutics to Host Virtual Event on Current Clinical Landscape in Alzheimer's Disease Treatment Options with Leaders and Experts on April 15th, 2021


01.04.2021 - 07:02 Uhr
Vivoryon Therapeutics N.V.: Vivoryon Therapeutics to Host Virtual Event on Current Clinical Landscape in Alzheimer s Disease Treatment Options with Leaders and Experts on April 15th, 2021
Vivoryon Therapeutics N.V., NL00150002Q7Despite repeated clinical trial failures in the AD space, a determined group of pharma and biotech companies has not given up on seeking for therapies that address the high unmet medical need in this indication. Vivoryon s interactive session will cover discussions surrounding current hurdles and exciting, novel approaches to the challenging AD space, including the company s clinical phase 2 compound, varoglutamstat, a small molecule inhibitor of glutaminyl cyclase (QC) capable of targeting all three hallmarks of AD: amyloid-beta, tau, and neuroinflammation. ....

Noord Holland , Ulrich Dauer , Halle Saale , Philip Scheltens , Howard Feldman , Frank Weber , Dementia Fund , English Company , Alzheimer Center Amsterdam , Department Of Neurosciences , Distribution Services , Alzheimer Disease Cooperative Study , Us National Institutes On , News Service , Communications Gretchen Schweitzer Valeria Fisher Tel , Disease Puzzle , Professor Philip Scheltens , Managing Partner , Disease Cooperative Study , California San Diego School , Chief Medical Officer , European Alzheimer , Disease Phase , Communications Gretchen Schweitzer , Valeria Fisher Tel , Forward Looking Statementsinformation ,