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Light-controlled on/off switch helps control biological clock in cultured cells, explanted tissue


Light-controlled on/off switch helps control biological clock in cultured cells, explanted tissue
The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally. Scientists from the Netherlands and Japan introduced a light-controlled on/off switch to a kinase inhibitor, which affects clock function. This gives them control of the biological clock in cultured cells and explanted tissue. They published their results on 26 May in
Nature Communications.
Life on Earth has evolved under a 24-hour cycle; of light and dark, hot and cold. As a result, our cells are synchronized to these 24-hour oscillations, says Wiktor Szymanski, Professor of Radiological Chemistry at the University Medical Center Groningen. Our circadian clock is regulated by a central controller in the suprachiasmatic nucleus, a region in the brain direct ....

Tsuyoshi Hirota , Ben Feringa , Wiktor Szymanski , Emily Henderson , Molecules At Nagoya University , Institute Of Transformative Bio , Nature Communications , Nagoya University , University Medical Center Groningen , University Of Groningen , Tour De , Radiological Chemistry , University Medical Center , Study First Author , Phd Student , Transformative Bio Molecules , எமிலி ஹென்டர்சன் , மூலக்கூறுகள் இல் நாகோயா பல்கலைக்கழகம் , நிறுவனம் ஆஃப் உருமாறும் உயிர் , இயற்கை தகவல்தொடர்புகள் , நாகோயா பல்கலைக்கழகம் , பல்கலைக்கழகம் மருத்துவ மையம் க்ராநிகந் , பல்கலைக்கழகம் ஆஃப் க்ராநிகந் , சுற்றுப்பயணம் டி , பல்கலைக்கழகம் மருத்துவ மையம் , படிப்பு முதல் நூலாசிரியர் ,

Resetting the biological clock by flipping a switch


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IMAGE: Reversible modulation of the circadian clock using chronophotopharmacology. Using light to interconvert two isomers of a photo-responsive small molecule, it is possible to pace cellular time. While irradiation with violet.
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Credit: Issey Takahashi
The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally. Scientists from the Netherlands and Japan introduced a light-controlled on/off switch to a kinase inhibitor, which affects clock function. This gives them control of the biological clock in cultured cells and explanted tissue. They published their results on 26 May in ....

Tsuyoshi Hirota , Ben Feringa , Wiktor Szymanski , Molecules At Nagoya University , Institute Of Transformative Bio , Nature Communications , Nagoya University , University Medical Center Groningen , University Of Groningen , Tour De , Radiological Chemistry , University Medical Center , Transformative Bio Molecules , Molecular Biology , Medicine Health , Metabolism Metabolic Diseases , Circadian Rhythm , Leep Sleep Disorders , Pharmaceutical Chemistry , மூலக்கூறுகள் இல் நாகோயா பல்கலைக்கழகம் , நிறுவனம் ஆஃப் உருமாறும் உயிர் , இயற்கை தகவல்தொடர்புகள் , நாகோயா பல்கலைக்கழகம் , பல்கலைக்கழகம் மருத்துவ மையம் க்ராநிகந் , பல்கலைக்கழகம் ஆஃப் க்ராநிகந் , சுற்றுப்பயணம் டி ,

Nanotechnology Now - Press Release: 3D design leads to first stable and strong self-assembling 1D nanographene wires


Home > Press > 3D design leads to first stable and strong self-assembling 1D nanographene wires
Schematic illustration of hierarchical structures of carbon nanofiber bundles made of bitten warped nanographene molecules.
CREDIT
NINS/IMS
Abstract:
Nanographene is flexible, yet stronger than steel. With unique physical and electronic properties, the material consists of carbon molecules only one atom thick arranged in a honeycomb shape. Still early in technological development, current fabrication methods require the addition of substituents to obtain a uniform material. Additive-free methods result in flimsy, breakable fibers until now.
3D design leads to first stable and strong self-assembling 1D nanographene wires
Tokyo, Japan | Posted on April 6th, 2021 ....

United States , Japan General , Jenny Pirillo , Taishi Nishihara , Kenichiro Itami , Kenta Kato , Nobuhiko Mitoma , Kiyofumi Takaba , Koji Yonekura , Taito Hatakeyama , Yusuke Nakanishi , Lawrencet Scott , Yasutomo Segawa , Takuma Kawada , Yuh Hijikata , Saori Maki Yonekura , Self Assembly , Institute Of Transformative Bio , Nagoya University , Collaboration Center , Itami Molecular Nanocarbon Project At Nagoya University , University Of Nevada , Japan Society For The Promotion Of Science , Wave Inc , Toyoaki Scholarship Foundation , School Of Science ,

3D design leads to first stable and strong self-assembling 1D nanographene wires


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IMAGE: Schematic illustration of hierarchical structures of carbon nanofiber bundles made of bitten warped nanographene molecules.
view more 
Credit: NINS/IMS
Nanographene is flexible, yet stronger than steel. With unique physical and electronic properties, the material consists of carbon molecules only one atom thick arranged in a honeycomb shape. Still early in technological development, current fabrication methods require the addition of substituents to obtain a uniform material. Additive-free methods result in flimsy, breakable fibers until now.
An international team of researchers has developed self-assembling, stable and strong nanographene wires. The results were published on March 24 in
Journal of the American Chemical Society. ....

United States , Japan General , Jenny Pirillo , Taishi Nishihara , Kenichiro Itami , Kenta Kato , Nobuhiko Mitoma , Kiyofumi Takaba , Koji Yonekura , Taito Hatakeyama , Yusuke Nakanishi , Lawrencet Scott , Yasutomo Segawa , Takuma Kawada , Yuh Hijikata , Saori Maki Yonekura , Development Division , National Institutes Of Natural Science , Technology Agency , Tokyo Metropolitan University , Institute Of Multidisciplinary Research For Advanced Materials , Institute Of Transformative Bio , Department Of Structural Molecular Science , Nagoya University , Collaboration Center , Itami Molecular Nanocarbon Project At Nagoya University ,