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Fecal transplant overcomes resistance to immunotherapy in melanoma patients

Fecal transplant overcomes resistance to immunotherapy in melanoma patients
Researchers at UPMC Hillman Cancer Center and the National Cancer Institute (NCI) demonstrate that changing the gut microbiome can transform patients with advanced melanoma who never responded to immunotherapy-;which has a failure rate of 40% for this type of cancer-;into patients who do.
The results of this proof-of-principle phase II clinical trial were published online today in
Science. In this study, a team of researchers from UPMC Hillman administered fecal microbiota transplants (FMT) and anti-PD-1 immunotherapy to melanoma patients who had failed all available therapies, including anti-PD-1, and then tracked clinical and immunological outcomes. Collaborators at NCI analyzed microbiome samples from these patients to understand why FMT seems to boost their response to immunotherapy. ....

Diwakar Davar , Francesg Mcglothlin , Hassane Zarour , Emily Henderson , Melanoma Immunotherapy Research , National Cancer Institute , University Of Pittsburgh School Medicine , Immunotherapy Program , Hillman Cancer Center , Cancer Center , Co Lead Author , Medical Oncologist , Cancer Immunology , Assistant Professor , Pittsburgh School , Glothlin Chair , Fecal Transplant , Clinical Trial , திவாகர் தவர் , எமிலி ஹென்டர்சன் , மெலனோமா நோயெதிர்ப்பு சிகிச்சை ஆராய்ச்சி , தேசிய புற்றுநோய் நிறுவனம் , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் பள்ளி மருந்து , நோயெதிர்ப்பு சிகிச்சை ப்ரோக்ர்யாம் , ஹில்மேன் புற்றுநோய் மையம் , புற்றுநோய் மையம் ,

Fecal Microbiome Transplant Converts Melanoma Immunotherapy Non-Responders into Responders

Fecal Microbiome Transplant Converts Melanoma Immunotherapy Non-Responders into Responders
February 5, 2021
Scientists at the NIH in collaboration with UPMC Hillman Cancer Center have shown how some patients with advanced melanoma that hasn’t responded to immune checkpoint inhibitor therapy, can be converted to immunotherapy responders by giving them a fecal microbiota transplant (FMT), taken from patients who had responded very well to immunotherapy. Results from the proof-of-principle Phase II study, reported in
Science, suggest that introducing certain fecal microorganisms into a patient’s colon may help individuals respond to drugs that enhance the immune system’s ability to recognize and kill tumor cells. ....

Diwakar Davar , Francesg Mcglothlin , Amiran Dzutsev , Hassane Zarour , Giorgio Trinchieri , Diwaker Davar , Melanoma Immunotherapy Research , Cancer Research , University Of Pittsburgh School Medicine , Immunotherapy Program , Laboratory Of Integrative Cancer Immunology , Hillman Cancer Center , Cancer Center , Integrative Cancer Immunology , Cancer Immunology , Pittsburgh School , Glothlin Chair , திவாகர் தவர் , திவக்கேர் தவர் , மெலனோமா நோயெதிர்ப்பு சிகிச்சை ஆராய்ச்சி , புற்றுநோய் ஆராய்ச்சி , பல்கலைக்கழகம் ஆஃப் பிட்ஸ்பர்க் பள்ளி மருந்து , நோயெதிர்ப்பு சிகிச்சை ப்ரோக்ர்யாம் , ஆய்வகம் ஆஃப் ஒருங்கிணைந்த புற்றுநோய் நோயெதிர்ப்பு , ஹில்மேன் புற்றுநோய் மையம் , புற்றுநோய் மையம் ,

Fecal transplant turns cancer immunotherapy non-responders into responders

Credit: UPMC
PITTSBURGH, Feb. 4, 2021 - Researchers at UPMC Hillman Cancer Center and the National Cancer Institute (NCI) demonstrate that changing the gut microbiome can transform patients with advanced melanoma who never responded to immunotherapy which has a failure rate of 40% for this type of cancer into patients who do.
The results of this proof-of-principle phase II clinical trial were published online today in Science. In this study, a team of researchers from UPMC Hillman administered fecal microbiota transplants (FMT) and anti-PD-1 immunotherapy to melanoma patients who had failed all available therapies, including anti-PD-1, and then tracked clinical and immunological outcomes. Collaborators at NCI analyzed microbiome samples from these patients to understand why FMT seems to boost their response to immunotherapy. ....

New York , United States , National Institutes Of Health , Marc Schwartz , Bochra Zidi , Carmine Menna , Francesg Mcglothlin , Amiran Dzutsev , Hassane Zarour , Ornella Pagliano , Giorgio Trinchieri , Amy Rose , Robert Morrison , Stephanie Prescott , Marie Vetizou , Shuowen Zhang , John Kirkwood , Cyndy Patton , Howard Dubner , Richelle Deblasio , Yana Najjar , Galicia Cole , Amir Borhani , Ivan Vujkovic Cvijin , Miriam Fernandes , Yasmine Belkaid ,