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High-dose buprenorphine in EDs may improve patient outcomes


By Susan Gonzalez
July 15, 2021
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The administration of high-dose buprenorphine therapy in hospital emergency departments (ED) may safely and rapidly diminish withdrawal symptoms and sustain craving suppression in people with opioid use disorder, improving their likelihood of accessing follow-up treatment, according to a study co-authored by Yale’s Gail D’Onofrio.
Buprenorphine is a medication approved by the U.S. Food and Drug Administration to treat opioid use disorder. Giving lower doses of the medication is the current standard of care. The study found, however, that giving higher doses of buprenorphine in EDs may provide a longer period of relief to people after they are discharged, which may help them navigate barriers to access to follow-up care before they experience withdrawal symptoms. ....

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Make Harm Reduction Federal Health Policy Now, Say Yale Experts


May 08, 2021
by Julie Parry
Since the start of the COVID-19 pandemic over a year ago, alcohol and substance use has surged in the United States, along with overdoses from opioids. To save lives, using practical strategies to reduce the negative effects of substance use, or harm reduction strategies should become federal health policy now, urges experts Kimberly Sue, MD, PhD, and David Fiellin, MD, from the Yale Program in Addiction Medicine.
The New England Journal of Medicine, they urge the Biden administration to name, embrace, and implement harm reduction programs to save American lives. In addition to expanding treatment, they argue, there is a need for additional measures to abate the tidal wave of death from overdoses. Additionally, they say funds should be allocated to combat the health inequities and racial injustice for Black Americans who are suffering from a disproportionate rise in deaths from substance use disorders, along with COVID-19. ....

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