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Collagen Plays Protective Role during Pancreatic Cancer Development


Collagen Plays Protective Role during Pancreatic Cancer Development
Scanning electron micrograph (SEM) of collagen bundles from the delicate connective tissue endoneurium. Endoneurium wraps around and between individual nerve fibers (axons), providing support and filling space between the nerve fibers. Endoneurium consists of collagen and elastin fibers and is found in the peripheral nervous system. The characteristic banding of collagen can be seen in this image. Magnification: x3000 when printed at 10 centimeters wide. [Steve Gschmeissner/Science Photo Library/Getty Images]
March 5, 2021
Scanning electron micrograph (SEM) of collagen bundles from the delicate connective tissue endoneurium. Endoneurium wraps around and between individual nerve fibers (axons), providing support and filling space between the nerve fibers. Endoneurium consists of collagen and elastin fibers and is found in the peripheral nervous system. The characteristic banding of collagen can be seen ....

United States , Raghu Kalluri , University Of Texas Md Anderson Cancer Center , Cancer Cell , ஒன்றுபட்டது மாநிலங்களில் , ரகு கல்லூரி , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , புற்றுநோய் செல் ,

Study clarifies the role of collagen during pancreatic cancer development


Study clarifies the role of collagen during pancreatic cancer development
Contrary to long-held beliefs, Type I collagen produced by cancer-associated fibroblasts may not promote cancer development but instead plays a protective role in controlling pancreatic cancer progression, reports a new study from researchers at The University of Texas MD Anderson Cancer Center. This new understanding supports novel therapeutic approaches that bolster collagen rather than suppress it.
The study finds that collagen works in the tumor microenvironment to stop the production of immune signals, called chemokines, that lead to suppression of the anti-tumor immune response. When collagen is lost, chemokine levels increase, and the cancer is allowed to grow more rapidly. The research was published today in ....

United States , Raghu Kalluri , Emily Henderson , University Of Texas Md Anderson Cancer Center , Cancer Biology , Senior Author , Pancreatic Cancer , Immune Response , ஒன்றுபட்டது மாநிலங்களில் , ரகு கல்லூரி , எமிலி ஹென்டர்சன் , பல்கலைக்கழகம் ஆஃப் டெக்சாஸ் ம்ட் ஆண்டர்சன் புற்றுநோய் மையம் , புற்றுநோய் உயிரியல் , மூத்தவர் நூலாசிரியர் , கணையம் புற்றுநோய் , நோய் எதிர்ப்பு சக்தி பதில் ,