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BioAtla Conditionally Active Biologic Antibody Design And Functionality For Cancer Treatment Described In Leading Scientific Journal Peer-Reviewed Paper


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SAN DIEGO, Feb. 22, 2021 /PRNewswire/ BioAtla, Inc., a global clinical-stage biotechnology company focused on the development of Conditionally Active Biologic (CAB) antibody therapeutics, today announced the publication by Proceedings of the National Academy of Sciences (PNAS) that describes the design and functionality of therapeutic antibody candidates utilizing BioAtla s proprietary CAB technology making them active only in the acidic tumor microenvironment while binding is reversibly inhibited in healthy tissue. This improved tumor targeting utilizes a newly discovered chemical switch system and is shown in animal models to provide for potent anti-tumor activity with markedly reduced toxicity to normal tissue, indicating a widened therapeutic index.  ....

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Historically Speaking: Hills of Dover NH have stories to tell


Anthony McManus
Many people may not think of Dover as a particularly hilly area, but in fact, from its very early years a number of locations have been identified specifically as heights of land. 
In today s world, with paved roads and structures of various kinds spread about, the landscape may seem more flattened and we may not be totally aware that we are dealing with some fairly dramatic inclines.  A motor vehicle makes it seem easy.  But think for a minute about our forbears in the 1700s and 1800s pushing a wheelbarrow or trying to maneuver a horse and wagon, the principal modes of transport of the times, on a muddy or icy unpaved roadway from one of the warehouses along the waterfront up the lower portion of Portland Avenue, or up what is now Rogers Street, slipping and sliding up or down what we know as George or Hanson streets, going south the length of Henry Law Ave (back then Payne Street), or (even today under some winter conditions) heading toward the hospi ....

Thomas Westbrook Waldron , Nathanial Swazey , Thomas Paine , William Horne , Betsey Cole , Swazey Hill , James Rawlings , Anthony Mcmanus , Thorne Hill , Felisha Thomas , Peter Drowne , Plato Waldron , Richard Waldron , Jabez Burroughs , Platte Hill , Varney Hill , Guppey Hill , George Brook , Plato Hill , Harrison Haley , Ebenezar Varney , Abbey Sawyer , First Parish Church , Baptist Society , Historically Speaking , Fosters Daily ,

BioAtla to Present at 39th Annual J.P. Morgan Virtual Healthcare Conference


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SAN DIEGO, Jan. 8, 2021 /PRNewswire/  BioAtla, Inc., a global clinical-stage biotechnology company focused on the development of Conditionally Active Biologic (CAB) antibody therapeutics, today announced that Jay M. Short, Ph.D., Chief Executive Officer, and Scott Smith, President, with participation by other BioAtla executives, will present at the 39
th Annual J.P. Morgan Virtual Healthcare Conference on Monday, January 11, 2021, at 2:50 PM Eastern Time. 
About BioAtla, Inc.
BioAtla is a global clinical-stage biotechnology company with operations in San Diego, California, and Beijing, China. Utilizing its proprietary Conditionally Active Biologics (CAB) technology, BioAtla develops novel monoclonal antibody and other protein therapeutic product candidates designed to have more selective targeting, greater efficacy, and more cost-efficient and predictable manufacturing than traditional antibodies. BioAtla has two progra ....

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