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Abnormal blood levels of proteins linked to dementia, Alzheimer's disease

The development of dementia, often from Alzheimer's disease, late in life is associated with abnormal blood levels of dozens of proteins up to five years earlier, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health ....

United States , Jingsha Chen , Eric Boerwinkle , Josef Coresh , Aozhou Wu , Nilanjan Chatterjee , Ron Hoogeveen , Emily Henderson , Natalie Daya , Georgew Comstock , Vilmundur Gudnason , Keenan Walker , Lori Jennings , Elias Gudmundsson , Rebecca Gottesman , Linda Zhou , Scott Zeger , Jingning Zhang , Yunju Yang , Thomas Mosley , Peter Ganz , Christie Ballantyne , Myriam Fornage , Kevin Sullivan , Valur Emilsson , Lenore Launer ,

Researchers identify proteins that predict future dementia, Alzheimer's risk

The development of dementia, often from Alzheimer s disease, late in life is associated with abnormal blood levels of dozens of proteins up to five years earlier. ....

United States , Jingsha Chen , Eric Boerwinkle , Josef Coresh , Aozhou Wu , Nilanjan Chatterjee , Ron Hoogeveen , Natalie Daya , Georgew Comstock , Vilmundur Gudnason , Keenan Walker , Lori Jennings , Elias Gudmundsson , Rebecca Gottesman , Linda Zhou , Scott Zeger , Jingning Zhang , Yunju Yang , Thomas Mosley , Peter Ganz , Christie Ballantyne , Myriam Fornage , Kevin Sullivan , Valur Emilsson , Lenore Launer , Bloomberg School ,

Midlife Brain Changes Seen with Asymptomatic Cardiac Disease

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Links between cardiovascular disease and cognitive decline may begin in midlife before the first clinical symptoms of either condition appear, cross-sectional data from a cohort study suggested.
Middle-age cardiovascular risk largely driven by hypertension was associated with brain hypometabolism, an imaging marker of neurodegeneration, according to Valentin Fuster, MD, PhD, of Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid, Spain, and Mount Sinai Hospital in New York City, and colleagues.
Subclinical carotid plaque burden also was tied to reduced brain metabolism independent of diabetes, hypertension, dyslipidemia, and smoking, they reported in the
When brain metabolism declines, the brain s ability to handle adverse events can be compromised. Depending on the brain area affected, this can lead to a range of distinct problems, co-author Marta Cortes-Canteli, PhD, also of CNIC, said in a statement. ....

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Controlling CVD Risk Factors May Also Protect Against Dementia

Feb 17, 2021
Hypertension had strongest link to midlife brain hypometabolism
What’s good for the heart is ultimately good for the brain, data from a prospective cohort study showed. The researchers noted that midlife cardiovascular risk especially hypertension in asymptomatic patients was tied to middle-age brain hypometabolism in areas known to be affected by dementia.
Subclinical carotid plaque burden was also associated with reduced brain metabolism independently of the cardiovascular disease (CVD) risk factors diabetes, hypertension, dyslipidemia, and smoking reported Valentin Fuster, MD, PhD, of Centro Nacional de Investigaciones Cardiovasculares in Madrid, Spain, and co-authors.
“The findings presented here suggest that the interplay between cardiovascular risk factors, atherosclerosis, and altered brain metabolism starts early in life,” they wrote in the ....

New York , United States , Rebecca Gottesman , Paul Smyth , Investigaciones Cardiovasculares , Salud Carlos , Neal Parikh , Valentin Fuster , European Regional Development Fund , Johns Hopkins University In Baltimore , Journal Of The American College Cardiology , European Social Fund , Banco Santander , American College , Early Subclinical Atherosclerosis , Framingham Risk Scores , Weill Cornell Medicine , New York City , Johns Hopkins University , Contributing Writer , Instituto De Salud Carlos , European Social , Leon Levy Fellowship , புதியது யார்க் , ஒன்றுபட்டது மாநிலங்களில் , ரிபேக்க கோத்டேஸ்மான் ,