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Phenotypes of Mild-to-Moderate Obstructive Pulmonary Disease


Purpose: Asthma and chronic obstructive pulmonary disease (COPD) are complex and heterogeneous inflammatory diseases. We sought to investigate distinct disease profiles based on clinical, cellular and molecular data from patients with mild-to-moderate obstructive pulmonary diseases.
Patients and Methods: Patients with mild-to-moderate allergic asthma (n=30) and COPD (n=30) were prospectively recruited. Clinical characteristics and induced sputum were collected. In total, 35 mediators were assessed in induced sputum. Logistic regression analysis was conducted to identify the optimal factors that were able to discriminate between asthma and COPD. Further, the data were explored using hierarchical clustering in order to discover and compare clusters of combined samples of asthma and COPD patients. Clinical parameters, cellular composition, and sputum mediators of asthma and COPD were assessed between and within obtained clusters. ....

United States , Waals Gewest , Eteläuomen Läi , Biomedica Medizinprodukte Gmb , Global Initiative For Chronic Obstructive Lung Disease , American Thoracic Society European Respiratory , University Of Warsaw , Statsoft Inc , R Foundation For Statistical Computing , Global Initiative For Asthma , Medical University , Global Initiative , Chronic Obstructive Lung , Port Washington , Ethics Committee , American Thoracic , European Respiratory Society , Elecsys Ige , Roche Diagnostics Gmbh , Bio Plex Pro , Human Cytokine , Bio Rad Laboratories , Demeditec Diagnostics Gmbh , Biomedica Medizinprodukte Gmbh , Whitneyu Test , Statistical Computing ,

Legal Profession Blog


Legal Profession Blog
The Delaware Supreme Court affirmed the denial of relief based on an alleged undisclosed judicial conflict
In 2010, Appellants Meso Scale Diagnostics, LLC and Meso Scale Technologies, LLC (collectively “Meso”) filed suit in the Court of Chancery against Appellee entities Roche Diagnostics GmbH, Roche Diagnostics Corp., Roche Holding Ltd., IGEN LS LLC, Lilli Acquisition Corp., IGEN International, Inc., and Bioveris Corp. (collectively “Roche”), all of which are or were affiliates or subsidiaries of the F. Hoffmann La Roche, Ltd. family of pharmaceutical and diagnostics companies. Meso alleged two counts of breach of contract. Roche prevailed at trial, and this Court affirmed the judgment in 2014. ....

United States , Mike Frisch , Appellants Meso Scale Diagnostics , Department Of Justice , Bioveris Corp , Vice Chancellors Of The Court , Roche Diagnostics Corp , International Inc , Lilli Acquisition Corp , Roche Holding Ltd , Meso Scale Technologies , Delaware Supreme Court , F Hoffmann La Roche Ltd , Roche Diagnostics Gmbh , Vice Chancellor , Vice Chancellors , Vice Chancellor Parsons , Chancery Rule , Web Communications , ஒன்றுபட்டது மாநிலங்களில் , மைக் ஃப்ரிஶ் , துறை ஆஃப் நீதி , துணை அதிபர்கள் ஆஃப் தி நீதிமன்றம் , ரோச் பரிசோதனை கார்ப் , சர்வதேச இன்க் , லில்லி கையகப்படுத்தல் கார்ப் ,

Roche Calls Meso's Bouchard-Related Bias Claims 'Weak'


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Roche Calls Meso s Bouchard-Related Bias Claims Weak
Law360 (December 9, 2020, 7:50 PM EST) Roche told the Delaware Supreme Court on Wednesday it should reject Meso Scale Diagnostics LLC s weak and thin arguments in its bid to reverse the Chancery Court s toss of a suit seeking to vacate a 2014 ruling allegedly tainted by now-Chancellor Andre G. Bouchard s work on that case.
During an oral argument held virtually, counsel for Roche Diagnostics GmbH took aim at Meso s appeal of a ruling by Vice Chancellor Joseph R. Slights III that rejected Meso s claim that now-retired Vice Chancellor Donald Parsons should have recused himself from deciding a prior intellectual property dispute between the companies because of alleged. ....

United States , Andreg Bouchard , Donald Parsons , Chancery Court , Meso Scale Diagnostics , Delaware Supreme Court On , Delaware Supreme Court , Chancellor Andre , Roche Diagnostics Gmbh , Vice Chancellor Joseph , Vice Chancellor Donald Parsons , ஒன்றுபட்டது மாநிலங்களில் , டொனால்ட் பார்சன்கள் , சான்சரி நீதிமன்றம் , மீசோ அளவு பரிசோதனை , டெலாவேர் உச்ச நீதிமன்றம் ஆன் , டெலாவேர் உச்ச நீதிமன்றம் , அதிபர் ஆண்ட்ரே , ரோச் பரிசோதனை கஂப் , துணை அதிபர் ஜோசப் , துணை அதிபர் டொனால்ட் பார்சன்கள் ,