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A Safer MRI Contrast Agent for High-resolution 3-D Microvascular Imaging


A Safer MRI Contrast Agent for High-resolution 3-D Microvascular Imaging
The new contrast agent offers a vast improvement over traditional gadolinium-based products
(a) High-resolution 3D MRI brain vascular map using SAIO. Various blood vessels in the rat brain can be visualized. In addition to clinically important brain vessels including anterior cerebral artery, middle cerebral artery, posterior cerebral artery, fine vessel structures as thin as ~ 100 microns in diameter can be clearly visualized. (b) 3D MRI brain vascular map using Dotarem (gadolinium-based contrast agent). Resolution is low and microvessels are not visible. (c) For 3D reconstruction, multiple slices of MRI images of the rat heart were obtained after injection of SAIO. Rat coronary arteries (180 microns) which are 10 times thinner than human coronary arteries were successfully visualized. Coronary arteries supply blood to the heart muscle and the blockage or narrowing of such arteries causes myocardial ....

Soult Ukpyolsi , South Korea , Lawrence Tanenbaum , Max Wintermark , Emanuel Kanal , Byoung Wook , Institute For Basic Science , Yonsei University , Yonsei University College Of Medicine , Basic Science , Yonsei University College , Supramolecular Amorphous Like Iron Oxide , Gadolinium Contrast Safety , Big Concerns Remain , Contrast Safety , Managing Gadolinium Safety , Show Serious , தெற்கு கொரியா , லாரன்ஸ் தானென்போஉம் , இமானுவேல் கனல் , நிறுவனம் க்கு அடிப்படை அறிவியல் , அடிப்படை அறிவியல் , மாறாக பாதுகாப்பு , எப்படி தீவிரமானது ,