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Lab reveals how an oral antiviral drug confuses the replication machinery of SARS-CoV-2

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IMAGE: Mutagenesis Model of Molnupiravir. SARS-CoV-2 polymerase (oval) mediated nucleotide incorporation into the RNA primer (grey circles)/template (white circles). Plus and minus sense indicate RNA sense. A, C, G, and U.
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Credit: Supplied by Matthias Gotte
A University of Alberta virology lab has uncovered how an oral antiviral drug works to attack the SARS-CoV-2 virus, in findings published May 10 in the
Journal of Biological Chemistry.
The researchers demonstrated the underlying mechanism of action by which the antiviral drug molnupiravir changes the viral genome, a process known as excessive mutagenesis or error catastrophe.
The polymerase, or replication engine of the virus, mistakes molnupiravir molecules for the natural building blocks required for viral genome replication and mixes them in, explained Matthias Götte, professor and chair of the Department of Medical Microbiology & Immunology in the Faculty of M ....

United States , Ridgeback Biotherapeutics , Raymond Schinazi , Egor Tchesnokov , Calvin Gordon , A University Of Alberta , World Health Organization , Alberta Ministry Of Jobs , Li Ka Shing Institute Of Virology , Canadian Institutes Of Health Research , Department Of Medical Microbiology Immunology , Emory School Of Medicine , Emory University In Atlanta , Us National Institutes Of Health Centers , Medical Microbiology , Emory University , Canadian Institutes , Health Research , Alberta Ministry , Health Centers , Emory School , ஒன்றுபட்டது மாநிலங்களில் , கால்வின் கோர்டந் , உலகம் ஆரோக்கியம் ஆர்கநைஸேஶந் , ஆல்பர்ட்டா அமைச்சகம் ஆஃப் வேலைகள் , லி கா ஷிங் நிறுவனம் ஆஃப் வைராலஜி ,

Economic optimism provides hope in the province's future | Grande Prairie Daily Herald Tribune

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Sure as a narrow band of clear sky on the western horizon, with storm clouds hanging overhead, there is a bright future ahead for the province.
Doug Schweitzer, Minister of Jobs, Economy and Innovation, addressed an audience from the Grande Prairie and District Chamber of Commerce about the provinceâs outlook.
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Economic optimism provides hope in the provinceâs future Back to video
âI think the biggest thing we are seeing right now and that we see for the second half of 2021 is going to be a rebound in some of our biggest economic drivers for the province of Alberta, namely being oil and gas,â said Schweitzer during an interview after the address. âWe are seeing a significant uptake in WTI (West Texas Intermediate oil) pricing, in particular. Right now, it is hovering in the mid-$US60 range. There are some forecasts having oil going up to t ....

United States , Grande Prairie , Doug Schweitzer , Randy Vanderveen , University Of Alberta , Calgary Chamber , District Chamber , Li Ka Shing Institute Of Virology , West Texas Intermediate , Nobel Prize Winning , ஒன்றுபட்டது மாநிலங்களில் , கிராண்டே ப்ரேரீ , டக் ஶ்வைட்ஸர் , ரேண்டி வந்தேருவீன் , பல்கலைக்கழகம் ஆஃப் ஆல்பர்ட்டா , கல்கரி அறை , மாவட்டம் அறை , லி கா ஷிங் நிறுவனம் ஆஃப் வைராலஜி , மேற்கு டெக்சாஸ் இடைநிலை , நோபல் ப்ரைஸ் வென்றது ,

Economic optimism provides hope in the province's future

Article content
Sure as a narrow band of clear sky on the western horizon, with storm clouds hanging overhead, there is a bright future ahead for the province.
Doug Schweitzer, Minister of Jobs, Economy and Innovation, addressed an audience from the Grande Prairie and District Chamber of Commerce about the provinceâs outlook.
We apologize, but this video has failed to load.
Try refreshing your browser.
Economic optimism provides hope in the provinceâs future Back to video
âI think the biggest thing we are seeing right now and that we see for the second half of 2021 is going to be a rebound in some of our biggest economic drivers for the province of Alberta, namely being oil and gas,â said Schweitzer during an interview after the address. âWe are seeing a significant uptake in WTI (West Texas Intermediate oil) pricing, in particular. Right now, it is hovering in the mid-$US60 range. There are some forecasts having oil going up to t ....

United States , Grande Prairie , Doug Schweitzer , Randy Vanderveen , University Of Alberta , Calgary Chamber , District Chamber , Li Ka Shing Institute Of Virology , West Texas Intermediate , Nobel Prize Winning , ஒன்றுபட்டது மாநிலங்களில் , கிராண்டே ப்ரேரீ , டக் ஶ்வைட்ஸர் , ரேண்டி வந்தேருவீன் , பல்கலைக்கழகம் ஆஃப் ஆல்பர்ட்டா , கல்கரி அறை , மாவட்டம் அறை , லி கா ஷிங் நிறுவனம் ஆஃப் வைராலஜி , மேற்கு டெக்சாஸ் இடைநிலை , நோபல் ப்ரைஸ் வென்றது ,

Economic optimism provides hope in the province's future | Peace River Record Gazette

Article content
Sure as a narrow band of clear sky on the western horizon, with storm clouds hanging overhead, there is a bright future ahead for the province.
Doug Schweitzer, Minister of Jobs, Economy and Innovation, addressed an audience from the Grande Prairie and District Chamber of Commerce about the provinceâs outlook.
We apologize, but this video has failed to load.
Try refreshing your browser.
Economic optimism provides hope in the provinceâs future Back to video
âI think the biggest thing we are seeing right now and that we see for the second half of 2021 is going to be a rebound in some of our biggest economic drivers for the province of Alberta, namely being oil and gas,â said Schweitzer during an interview after the address. âWe are seeing a significant uptake in WTI (West Texas Intermediate oil) pricing, in particular. Right now, it is hovering in the mid-$US60 range. There are some forecasts having oil going up to t ....

United States , Grande Prairie , Doug Schweitzer , Randy Vanderveen , University Of Alberta , Calgary Chamber , District Chamber , Li Ka Shing Institute Of Virology , West Texas Intermediate , Nobel Prize Winning , ஒன்றுபட்டது மாநிலங்களில் , கிராண்டே ப்ரேரீ , டக் ஶ்வைட்ஸர் , ரேண்டி வந்தேருவீன் , பல்கலைக்கழகம் ஆஃப் ஆல்பர்ட்டா , கல்கரி அறை , மாவட்டம் அறை , லி கா ஷிங் நிறுவனம் ஆஃப் வைராலஜி , மேற்கு டெக்சாஸ் இடைநிலை , நோபல் ப்ரைஸ் வென்றது ,

Opinion: If we want to be ready for the next pandemic, Canada's biotech industry will need to be stronger

The Globe and Mail
Opinion
If we want to be ready for the next pandemic, Canada’s biotech industry will need to be stronger
Michael Houghton and D. Lorne Tyrrell
Contributed to The Globe and Mail
Published April 15, 2021
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Michael Holly/The Canadian Press
Michael Houghton is the director of the University of Alberta’s Li Ka Shing Applied Virology Institute and the winner, in October, of the ....

Sanofi Pasteur , D Lorne Tyrrell , Michael Houghton , Michael Holly , University Of Alberta , Department Of Medical Microbiology , Li Ka Shing Institute Of Virology , Groupa Streptococcus , Medical Microbiology , Covid 19 , Biotech Industry , சனோஃபி பாஸ்டர் , ட லார்ன் டைரெல் , மைக்கேல் ஹ Ought க்டன் , மைக்கேல் ஹோலி , பல்கலைக்கழகம் ஆஃப் ஆல்பர்ட்டா , துறை ஆஃப் மருத்துவ நுண்ணுயிரியல் , லி கா ஷிங் நிறுவனம் ஆஃப் வைராலஜி , மருத்துவ நுண்ணுயிரியல் , சர்வதேச பரவல் , பயோடெக் தொழில் ,