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BOSTON - Researchers at Massachusetts General Hospital (MGH) have uncovered new clues that add to the growing understanding of how female mammals, including humans, silence one X chromosome. Their new study, published in
Molecular Cell, demonstrates how certain proteins alter the architecture of the X chromosome, which contributes to its inactivation. Better understanding of X chromosome inactivation could help scientists figure out how to reverse the process, potentially leading to cures for devastating genetic disorders.
Female mammals have two copies of the X chromosome in all of their cells. Each X chromosome contains many genes, but only one of the pair can be active; if both X chromosomes expressed genes, the cell couldn t survive. To prevent both X chromosomes from being active, female mammals have a mechanism that inactivates one of them during development. X chromosome inactivation is orchestrated by a noncoding form of RNA called Xist, which sil ....

United States , Jeannie Lee , Andrea Kriz , Department Of Molecular Biology , Lee Laboratory , Genetics At Harvard Medical School , Massachusetts General Hospital , Molecular Cell , Molecular Biology , Harvard Medical , Sex Linked Conditions , ஒன்றுபட்டது மாநிலங்களில் , ஜீனி லீ , துறை ஆஃப் மூலக்கூறு உயிரியல் , லீ ஆய்வகம் , ஜெநெடிக்ஸ் இல் ஹார்வர்ட் மருத்துவ பள்ளி , மாசசூசெட்ஸ் ஜநரல் மருத்துவமனை , மூலக்கூறு செல் , மூலக்கூறு உயிரியல் , ஹார்வர்ட் மருத்துவ , செக்ஸ் இணைக்கப்பட்டுள்ளது நிபந்தனைகள் ,