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Kynurenic acid may underlie sex-specific immune responses to COVID-19

Kynurenic acid may underlie sex-specific immune responses to COVID-19
sciencemag.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from sciencemag.org Daily Mail and Mail on Sunday newspapers.

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'Turncoat' antibodies are major culprits in severe COVID-19

Rogue antibodies are major culprits in severe cases of COVID-19, researchers report.
These autoantibodies target and react with a person’s tissues or organs similar to ones that cause autoimmune diseases such as lupus or rheumatoid arthritis. In COVID-19 cases they can attack healthy tissue in brain, blood vessels, platelets, liver, and the gastrointestinal tract, researchers report. The more autoantibodies detected, the greater the disease severity patients experience.
And the autoantibodies paradoxically also target and interfere with many immune system proteins that are designed to fend off infections, according to a new study.
The development of antibodies in response to the COVID-19 virus has been the great long-term hope for ending the pandemic, but it might not be so simple. ....

Yile Dai , Akiko Iwasaki , Seranova Bio , Eric Wang , Yale University , Ludwig Family Foundation , Mathers Family Foundation , Aaron Ring , Rapid Extracellular Antigen Profiling , எரிக் வாங் , யேல் பல்கலைக்கழகம் , லுட்விக் குடும்பம் அடித்தளம் , ஆரோன் மோதிரம் ,

Rogue antibodies wreak havoc in severe COVID-19 cases

By Bill Hathaway
May 19, 2021
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The development of antibodies to the COVID-19 virus has been the great long-term hope of ending the pandemic. However, immune system turncoats are also major culprits in severe cases of COVID-19, Yale scientists report in the journal Nature.
These autoantibodies target and react with a person’s tissues or organs similar to ones that cause autoimmune diseases such as lupus or rheumatoid arthritis. In COVID-19 cases they can attack healthy tissue in brain, blood vessels, platelets, liver, and the gastrointestinal tract, researchers report. The more autoantibodies detected, the greater the disease severity experienced by patients. ....

Yile Dai , Akiko Iwasaki , Jon Klein , Seranova Bio , Eric Wang , Tianyang Mao , Ludwig Family Foundation , Yale College , Mathers Family Foundation , Aaron Ring , Waldemar Von Zedtwitz Professor , Rapid Extracellular Antigen Profiling , Yale Immunobiology , Ludwig Family , Yale University , Press Releases , ஜான் க்ளீன் , எரிக் வாங் , லுட்விக் குடும்பம் அடித்தளம் , யேல் கல்லூரி , ஆரோன் மோதிரம் , லுட்விக் குடும்பம் , யேல் பல்கலைக்கழகம் ,

Study offers an explanation for why the APOE4 gene enhances Alzheimer's risk

Study offers an explanation for why the APOE4 gene enhances Alzheimer’s risk
March 4, 2021MIT
The gene variant disrupts lipid metabolism, but in cell experiments the effects were reversed by choline
One of the most significant genetic risk factors for developing Alzheimer’s disease is a gene called APOE4, which is carried by almost half of all Alzheimer’s patients. A new study from MIT shows that this gene has widespread effects on brain cells’ ability to metabolize lipids and respond to stress.
In studies of human brain cells and yeast cells, the researchers found that the APOE4 gene significantly disrupts brain cells’ ability to carry out their normal functions. They also showed that treating these cells with extra choline, a widely available supplement that is considered safe for human use, could reverse many of these effects. ....

Grzegorz Sienski , Julia Maeve Bonner , Susan Lindquist , Stephen Ross , Priyanka Narayan , Li Huei Tsai , Helen Hay Whitney Foundation , Whitehead Institute For Biomedical Research , Damon Runyon Foundation , National Institutes Of Health , Picower Institute For , Reneee Belfer Foundation , Neurodegeneration Consortium , Ludwig Family Foundation , Howard Hughes Medical Institute , Biomedical Research , Science Translational , Julia Maeve , National Institutes , ஜூலியா மயெவ் பொன்னர் , சூசன் லிண்ட்கிஸ்ட் , ஸ்டீபன் ரோஸ் , பிரியாங்க நாராயண் , ஹெலன் வைக்கோல் விட்னி அடித்தளம் , வைட்ஹெட் நிறுவனம் க்கு உயிர் மருத்துவ ஆராய்ச்சி , டாமன் றுஞயோன் அடித்தளம் ,