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Scientists identify severe asthma species, show air pollutant as likely contributor


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Sun Apr 25 2021
An epidemiological study has shown that not only is non-Th2 a distinct asthma disease, its likely inducer is early childhood exposure to airborne Benzo[a]pyrene, a byproduct of fossil fuel combustion.
 
Asthma afflicts more than 300 million people worldwide. The most severe manifestation, known as non-Th2, or non-atopic childhood asthma, represents the majority of the cases, greater than 85%, particularly in low-income countries, according to Hyunok Choi, an associate professor at the Lehigh University College of Health. Yet, whether non-Th2 is a distinct disease (or endotype) or simply a unique set of symptoms (or phenotype) remains unknown.
“Non-Th2 asthma is associated with very poor prognosis in children and great, life-long suffering due to the absence of effective therapies,” says Choi. “There is an urgent need to better understand its mechanistic origin to enable early diagnosis and to stop the progression of the disease before ....

Czech Republic , Hyunok Choi , Lehigh University College Of Health , Environmental Health Journal , Lehigh University College , Benzopyrene May Contribute , Divergent Pheno Endotypes , Southern Bohemia , செக் குடியரசு , லேஹி பல்கலைக்கழகம் கல்லூரி ஆஃப் ஆரோக்கியம் , சுற்றுச்சூழல் ஆரோக்கியம் இதழ் , லேஹி பல்கலைக்கழகம் கல்லூரி , தெற்கு போஹேமியா ,

Early exposure to air pollutant may contribute to non-atopic childhood asthma


Early exposure to air pollutant may contribute to non-atopic childhood asthma
Apr 15 2021
Asthma afflicts more than 300 million people worldwide. The most severe manifestation, known as non-Th2, or non-atopic childhood asthma, represents the majority of the cases, greater than 85%, particularly in low-income countries, according to Hyunok Choi, an associate professor at the Lehigh University College of Health. Yet, whether non-Th2 is a distinct disease (or endotype) or simply a unique set of symptoms (or phenotype) remains unknown.
Oil Refinery along Texas Gulf Coast. Photo: iStock/RoschetzkyIstockPhoto
Non-Th2 asthma is associated with very poor prognosis in children and great, life-long suffering due to the absence of effective therapies. There is an urgent need to better understand its mechanistic origin to enable early diagnosis and to stop the progression of the disease before it becomes severe.” ....

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Forecast: the impacts of vaccines and variants on the U.S. COVID trajectory


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In a report summary released today Thomas McAndrew, a computational scientist and assistant professor at Lehigh University s College of Health includes probabilistic forecasts of the impact of vaccines and variants on the U.S. COVID trajectory over the next few weeks. The goal of the report, says McAndrew, is to support public health officials, infectious disease modeling groups, and the general public
Report highlights:
A consensus of 91 forecasters predicts that the B.1.1.7. variant will be found in 42% of all genetic sequences with an S-gene mutation in the first two weeks of March and in 72% in all sequences between March 29 and April 4, 2021. ....

Thomas Mcandrew , Juan Cambeiro , Allison Codi , Damon Luk , Tamay Besiroglu , David Braun , Eva Chen , Luis Enrique Urtubey , Centers For Disease , Good Judgement Inc , Lehigh University , Lehigh University College Of Health , Good Judgment Open , Disease Control , Territorial Epidemiologists , Integrated Degree , Computer Science , Cognitive Psychology , Good Judgement , Medicine Health , Infectious Emerging Diseases , தாமஸ் அம்கெஂட்ர்யூ , அல்லிசன் கோடி , டாமன் லுக் , டேவிட் மூளை , ஈவா சென் ,