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Cyclophilin A Plays Potential Roles in a Rat Model of Asthma and Suppr


45 Meanwhile, this protective effect of CypA was also found in cardiomyocytes.
46 Oxidative stress is believed to contribute to asthma pathogenesis, and a previous study reported that antioxidant therapy can be useful for asthma.
47 Therefore, the mechanisms of CypA on oxidative stress involved in asthma should be noted. Thus far, our understanding of the mechanisms of CypA is far from complete. The role of CypA in the functioning of asthma with regard to the mechanism of reducing the RL and the isometric tension of tracheal spiral is unknown and is the subject of further study.
Conclusion
In summary, this work has demonstrated the effects of rCypA in asthma in both OVA-challenged asthmatic rats in vivo and ACh-induced contraction tracheal spirals ex vivo. The study also identified the underlying mechanism by which rCypA may have a precise role in limiting inflammation in asthma by suppressing the secretion of Th2 cytokines and balancing the ratio of Th1/Th2 cytoki ....

United States , Cyclophilina Cyp , Merck Millipore , Microbeads Miltenyi Biotec , Beyotime Biotechnology Co , Suspension Array System Bio Rad Laboratories Inc , Hans Rudolf Inc , Tianjin Biochem Pharmaceutical Co , Aldrich Co , Kent Scientific Corporation , Shanghai Aibi Chemical Reagent Co , Laboratory Animal Co , Shanghai Experimental Animal Centre , Shanghai Medical College , Chinese Academy Of Sciences , Bio Rad Laboratories Inc , Chengdu Huayu Pharmaceutical Co , Fudan University , Danaher Corporation Life Sciences , Xu Shen Shanghai Institute Of Materia Medica , Shanghai Institute , Materia Medica , Chinese Academy , Beyotime Biotechnology , Ovalbumin Challenged Asthmatic Rats , Chengdu Huayu Pharmaceutical ,

Cancer control: Non-DNA changes induce metabolism variations in hepatocellular carcinomas


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Credit: Cancer Biology & Medicine
Cancer cells acquire growth advantages over normal cells in myriad ways. Changes in cell programming allow these cells to grow in an uncontrolled fashion, thereby forming the cancer mass. Hepatocellular carcinoma (HCC), being highly malignant and invasive with a high recurrence rate and drug resistant phenotype, is one of the most dreadful cancers. Understanding the underlying molecular mechanisms is crucial to design therapeutic interventions and to predict patient prognosis.
Cancer cells use metabolic, immunogenic, or growth-related strategies, which can be controlled by a number of alterations in the cell process. Of these, post-transcriptional RNA modification has recently sparked interest among cancer biologists. N6-methyladenosine (m6A) methylation, a type of RNA modification, remains the most abundant epigenetic (non-DNA related) modification in eukaryotic cells. Abnormal activity of proteins that handle m6A re ....

Wei Qin , Lun Xiu Qin , Ryan Fu , Qiongzhu Dong , Lunxiu Qin , Jing Xu , Xiaotian Shen , Institutes Of Biomedical Sciences , Fudan University , International Cancer Genome Consortium , Shanghai Medical College , Huashan Hospital Cancer Metastasis Institute , Cancer Biology , Cancer Genome Atlas , Shun Wang , General Surgery , Huashan Hospital , Cancer Metastasis Institute , Biomedical Sciences , Cell Biology , Developmental Reproductive Biology , Medicine Health , வெய் குயின் , லூந் க்ஷிு குயின் , யான் ஃபூ , ஜிங் ஐயூ ,

Exchanges at Home and Abroad – Academicians and Experts Gathered, The 2020 Convention on Exchange of Overseas Talents Officially Opened


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On December 18th, the 2020 Convention on Exchange of Overseas Talents and the 22
nd Guangzhou Convention of Overseas Chinese Scholars in Science and Technology, co-sponsored by the Ministry of Education, the Western Returned Scholars Association (the Chinese Overseas-educated Scholars Association) and the Guangzhou Municipal Government, and co-organized by 29 cities (institutions) including Beijing, Tianjin, Shanghai and Chongqing, officially kicked off.
Li Yizhong, former minister of the Ministry of Industry and Information Technology and president of China Industry and Economy League, Zhang Shuofu, member of the Standing Committee of Guangdong Provincial Party Committee and secretary of Guangzhou Municipal Party Committee, Yu Hongjun, former deputy minister of the International Liaison Department of the CPC Central Committee and deputy director of the National Institute of Innovation and Development Strategy of the Chinese Academy of Sciences, Wang Xunzhang, ....

Hong Kong , Zeng Fang , Macau General , Wang Xunzhang , Xu Yongji , Ziyu Yan , Li Xuetong , Peter Sachsenmeier , Lin Xinhua , Jin Li , Xia Wenfeng , Zhang Shuofu , Sun Qilin , Wang Yanru , Li Jie , Li Yizhong , Zou Peng , Xu Zongben , Guangdong Hong Kong , Yu Hongjun , Expert Service Center , Guangzhou Municipal Party Committee , Japanese Academy Of Engineering , Xian Jiaotong University , Economy League , Business Incubation Center ,