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Study shows how melanomas assist T cells from identifying and killing tumor cells


Study shows how melanomas assist T cells from identifying and killing tumor cells
Cancers like melanoma are hard to treat, not least because they have a varied bag of tricks for defeating or evading treatments.
Now, a combined research effort by the Weizmann Institute of Science, the Netherlands Cancer Institute in Amsterdam, and the University of Oslo shows exactly how tumors, in their fight to survive, will go so far as to starve themselves in order to keep the immune cells that would eradicate them from functioning. The work was published in
Nature.
The immunotherapies currently administered for melanomas work by removing obstacles that keep immune cells called T cells from identifying and killing tumor cells. Recent research suggested that, in melanoma, another blocker – one that stops IDO1, an enzyme that is overproduced by cancer cells – could also assist the T cells. ....

Noord Holland , Reuven Agami , Yishai Levin , Yardena Samuels , Johanna Olweus , Emily Henderson , Department Of Molecular Genetics , Weizmann Institute Of Science , Department Of Molecular Cell Biology , Weizmann Institute , Netherlands Cancer Institute , University Of Oslo , Stephen Grand Israel National Center , Molecular Cell Biology , Noam Stern Ginossar , Molecular Genetics , Personalized Medicine , நூற்த் ஹாலண்ட் , எமிலி ஹென்டர்சன் , துறை ஆஃப் மூலக்கூறு ஜெநெடிக்ஸ் , வெய்ஸ்மேன் நிறுவனம் ஆஃப் அறிவியல் , துறை ஆஃப் மூலக்கூறு செல் உயிரியல் , வெய்ஸ்மேன் நிறுவனம் , நெதர்லாந்து புற்றுநோய் நிறுவனம் , பல்கலைக்கழகம் ஆஃப் ஒசிலோ , ஸ்டீபன் மாபெரும் இஸ்ரேல் தேசிய மையம் ,