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Tumor-promoting immune cells retrained to fight most aggressive type of brain cancer

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BOSTON - It s a real-life plot worthy of a classic spy novel: Researchers at Massachusetts General Hospital (MGH), the Dana-Farber Cancer Institute and other Boston-area research centers are turning the tables on glioblastomas, the most devastating and aggressive form of brain cancer, by transforming a type of cell that normally protects tumors and inhibits effective drug therapy into a stone-cold glioblastoma killer.
Glioblastoma, a type of brain tumor, is rapidly fatal: Most patients die within two years of diagnosis despite aggressive therapies such as brain surgery, whole-brain radiation and chemotherapy.
Despite hopes that a class of drugs known as immune checkpoint blockers (ICBs) - drugs that have revolutionized the treatment of patients with malignant melanoma, non-small-cell lung cancer, and other solid tumors - could also benefit patients with glioblastoma, ICBs have not been effective against the disease in clinical trials to date. ....

United States , Dana Farber Cancer Institute , Edwinl Steele , Rakeshk Jain , Hye Jung Kim , Zohreh Amoozgar , Dai Fukumura , Nature Communications , Jane Trust Foundation , National Institutes Of Health , Harvard Medical School , National Foundation For Cancer Research , Research Institute , Harvard Ludwig Cancer Center , Department Of Radiation Oncology , Research Foundation , Massachusetts General Hospital , Radiation Oncology , Andrew Werk Cook Professor , Dana Farber Cancer , National Institutes , National Foundation , Cancer Research , Advanced Medical Research Foundation , Harvard Medical , Mass General Research Institute ,

Exercise benefit in breast cancer linked to improved immune responses

Physical exercise increases levels of cancer-fighting immune cells in animal models of breast cancer and slows the growth of tumors. In addition to lowering risk of developing cancer, structured exercise programs could help improve therapy for females with existing breast tumors. Exercise may also significantly improve treatment of breast cancer with immunotherapy drugs. ....

United States , Igorl Gomes Santos , Edwinl Steele , Rakeshk Jain , Dai Fukumura , Cancer Immunology Research , National Institutes Of Health To Fukumura , Sao Paulo Research Foundation Brazil , Jane Trust Foundation To Jain , Harvard Medical School , National Foundation For Cancer Research , Harvard Ludwig Cancer Center , Department Of Radiation Oncology , Research Foundation , Massachusetts General Hospital , Radiation Oncology , Steele Labs , Andrew Werk Cook Professor , National Institutes , National Foundation , Cancer Research , Advanced Medical Research Foundation , Trust Foundation , Sao Paulo Research Foundation , Medicine Health , Breast Cancer ,

Ideas, Inventions And Innovations : COVID-19 Unmasked: Math Model Suggests Optimal Treatment Strategies

Ideas, Inventions And Innovations
COVID-19 Unmasked: Math Model Suggests Optimal Treatment Strategies
A biology-based mathematical model indicates why COVID-19 outcomes vary widely and how therapy can be tailored to match the needs of specific patient groups.
Getting control of COVID-19 will take more than widespread vaccination; it will also require better understanding of why the disease causes no apparent symptoms in some people but leads to rapid multi-organ failure and death in others, as well as better insight into what treatments work best and for which patients.

Credit: CDC/ Alissa Eckert, MS; Dan Higgins, MAMS
To meet this unprecedented challenge, researchers at Massachusetts General Hospital (MGH), in collaboration with investigators from Brigham and Women s Hospital and the University of Cyprus, have created a mathematical model based on biology that incorporates information about the known infectious machinery of SARS-CoV-2, the virus that ....

United States , Dan Higgins , Mohammad Reza Nikmaneshi , Alissa Eckert , Edwinl Steele , Sayon Dutta , Triantafyllos Stylianopoulos , Chrysovalantis Voutouri , Rakeshk Jain , Katie Marquedant , Lancel Munn , C Corey Hardin , Ashish Verma , Melinj Khandekar , Ankitb Patel , Jane Trust Foundation , National Institutes Of Health , Harvard Medical School , National Foundation For Cancer Research , Sharif University Of Technology , Proceedings Of The National Academy Sciences , Harvard Ludwig Cancer Center , American Medical Research Foundation , University Of Cyprus , European Research Council , Department Of Radiation Oncology ,

Math model suggests optimal coronavirus treatment strategies

Getting control of COVID-19 will take more than widespread vaccination; it will also require better understanding of why the disease causes no apparent symptoms in some people but leads to rapid multi-organ failure and death in others, as well as better insight into what treatments work best and for which patients.
To meet this unprecedented challenge, researchers at Massachusetts General Hospital (MGH), in collaboration with investigators from Brigham and Women’s Hospital and the University of Cyprus, have created a mathematical model based on biology that incorporates information about the known infectious machinery of SARS-CoV-2, the virus that causes COVID-19, and about the potential mechanisms of action of various treatments that have been tested in patients with COVID-19. ....

United States , Mohammad Reza Nikmaneshi , Edwinl Steele , Sayon Dutta , Triantafyllos Stylianopoulos , Chrysovalantis Voutouri , Rakeshk Jain , Lancel Munn , C Corey Hardin , Ashish Verma , Melinj Khandekar , Ankitb Patel , Jane Trust Foundation , National Institutes Of Health , Harvard Medical School , National Foundation For Cancer Research , Sharif University Of Technology , Proceedings Of The National Academy Sciences , Harvard Ludwig Cancer Center , American Medical Research Foundation , University Of Cyprus , European Research Council , Department Of Radiation Oncology , Innovation Foundation , Cyprus Research , Massachusetts General Hospital ,