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Deep dive into key COVID-19 protein is step toward new drugs, vaccines


Virus nucleocapsid protein is a prime target for disease-fighting interventions
The virus s nucleocapsid protein is a prime target for disease-fighting interventions.
April 22, 2021
Researchers at Oregon State University have taken a key step toward new drugs and vaccines for combating COVID-19 with a detailed biophysical study of one protein s interactions with the SARS-CoV-2 genetic material; SARS CoV-2 is the virus that causes COVID-19. A U.S. National Science Foundation grant supported the research.
The virus nucleocapsid protein, or N protein, has multiple functions, including packaging the RNA genome and interacting with other structural proteins during virion assembly. The N protein has critical roles in the coronavirus infection cycle and, because it mutates at a comparatively slow pace, drugs and vaccines targeting the N protein could be highly effective for longer periods of time, making them less susceptible to resistance. ....

Elisar Barbar , Manju Hingorani , Heather Masson Forsythe , Research News , Division Of Molecular , Researchers At Oregon State University , A Us National Science Foundation , Oregon State University , Science Foundation , Biophysical Journal , Cellular Biosciences , மஞ்சு ஹிங்கோரணி , ஹீத்தர் மாஸன் ஃபார்‌ஸைத் , ஆராய்ச்சி செய்தி , பிரிவு ஆஃப் மூலக்கூறு , ஆராய்ச்சியாளர்கள் இல் ஓரிகந் நிலை பல்கலைக்கழகம் , ஓரிகந் நிலை பல்கலைக்கழகம் , அறிவியல் அடித்தளம் , உயிர் இயற்பியல் இதழ் , செல்லுலார் உயிர் அறிவியல் ,

Deep dive into key COVID-19 protein is a step toward new drugs, vaccines


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IMAGE: The nucleocapsid phosphoprotein (blue) of SARS-CoV-2 (N) (grey) plays critical roles in multiple processes of the SARS-CoV-2 infection cycle, including replication and transcription, and packaging and protecting the genomic RNA.
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Credit: OSU College of Science
CORVALLIS, Ore. - Researchers in the Oregon State University College of Science have taken a key step toward new drugs and vaccines for combating COVID-19 with a deep dive into one protein s interactions with SARS-CoV-2 genetic material.
The virus nucleocapsid protein, or N protein, is a prime target for disease-fighting interventions because of the critical jobs it performs for the novel coronavirus infection cycle and because it mutates at a comparatively slow pace. Drugs and vaccines built around the work of the N protein carry the potential to be highly effective and for longer periods of time - i.e., less susceptible to resistance. ....

University Of Oregon , United States , Oregon State University , Elisar Barbar , James Prell , Patrick Reardon , Joaquin Rodriguez , Phillip Zhu , Amber Rolland , Heather Masson Forsythe , Seth Pinckney , Richard Cooley , Mj Murdock Charitable , Division Of Molecular , Oregon State University College Of Science , National Institutes Of Health , Oregon State University College , Biophysical Journal , Oregon State , National Science Foundation Early Concept Grant , Exploratory Research , National Institutes , Charitable Trust , Chemistry Physics Materials Sciences , Biomechanics Biophysics , பல்கலைக்கழகம் ஆஃப் ஓரிகந் ,