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Creating a safe CAR T-Cell therapy to fight solid tumors in children


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Chimeric Antigen Receptor T-cell therapy CAR T has revolutionized leukemia treatment. Unfortunately, the therapy has not been effective for treating solid tumors including childhood cancers such as neuroblastoma. Preclinical studies using certain CAR T against neuroblastoma revealed toxic effects. Now, a group of scientists at Children s Hospital Los Angeles have developed a modified version of CAR T that shows promise in targeting neuroblastoma, spares healthy brain tissue and more effectively kills cancer cells. Their study was published today in
Nature Communications. While this work is in the preclinical phase, it reveals potential for lifesaving treatment in children and adults with solid tumors. ....

United States , Sakunthala Muthugounder , Hamid Bassiri , Rachelle Tibbetts , Shahab Asgharzadeh , Davidm Barrett , Los Angeles , Hiroyuki Shimada , Michaeld Hogarty , Babak Moghimi , Nature Communications , Blood Disease Institute , Chimeric Antigen Receptort Cell , Hospital Los Angeles , Samy Jambon , Long Hung , ஒன்றுபட்டது மாநிலங்களில் , ரேச்சல் தீப்பெடட்ச் , லாஸ் ஏஞ்சல்ஸ் , ஹீரோயுக்கி ஶிமாட , இயற்கை தகவல்தொடர்புகள் , இரத்தம் நோய் நிறுவனம் , மருத்துவமனை லாஸ் ஏஞ்சல்ஸ் , நீண்டது தொங்கவிடப்பட்டது ,