At 95 years young hilda jaffe is setting an example and scientists think drugs could soon help the rest of us. Also on the programme. Allegations about hollywood producer Harvey Weinstein. We hear from a former colleague who tells us about her experience. 500 year old leftovers what these turkey bones tell us about tra ns atla ntic trade in the 1500s. Get in touch with us using the hashtag beyond 100 days. Hello and welcome im katty kay in washington and Christian Fraser is in london. Donald trump has ordered his top officials to refine a military plan to deal with north korea. In an interview with the bbc the Us National Security adviser hr mcmaster says the United States has to be prepared, if necessary, to compel north korea to end its Nuclear Weapons programme, with or without their cooperation. Last week the secretary of state Rex Tillerson hinted the us was ready to talk to north korea without preconditions. But the comments from the National Security advisor seem to contradict that view. General mcmasters been speaking to our colleague, yalda hakim. Are you committed to peaceful resolution to this . Of course, thats what we want but were not committed to a peaceful, but a resolution. We want it to be peaceful but as the president said, all options are on the table and we have to be prepared if necessary to compel the denuclearisation of north korea without the cooperation of that regime. Leading republicans, such as senator Lindsey Graham have said there is a 30 chance of war. If they continue with the strikes it could go up to 70 . Is war imminent . The chances of war could go up and down based on what we all decide to do. North korea is a great threat to all civilised people across the globe. Now is not the time to talk. We need to see a fundamental shift and conditions. We cannot afford any more to repeat the mistakes of the pass. Would you be willing to talk to the North Koreans bilaterally and hear them out . Under what conditions . No conditions. Under what conditions . There was no agenda, just talk. That is going to be up to the president to decide that what is create now is that we cannot in any way the efforts to continue the isolation of the regime diplomatically and economically. What has happened in the past as north korea has entered into talks to get the pressure relieved, and fennel stalks that nothing but still of the ability for the north to continue its programmes and checked. That Winter Olympics are coming up in february 2018 and south korea, would you feel safe sending your family there . Yes, we have a very Strong Alliance capability between the south Korean Armed Forces and oui the south Korean Armed Forces and our armed forces. When you extend that regionally, what this crisis is doing is that is driving our allies closer and closer together with us and in particular south korea, japan and in particular south korea, japan and the United States. All of the Us Intelligence communities have said that russia interfered in the 2016 elections. Putting the politics to one side, would you say that this is a National Security risk and threat . Certainly it is. With this strategy, we say explicitly in the document that the strategy views the world as it is, it does not create an aspirational model, so thats what we have to view russian behaviour as, look at what they are actually doing. Of course we have to counter their destabilising behaviour and the Sophisticated Campaigns of propaganda and disinformation, efforts to polarise communities and pit them against each other especially in the democratic world in a free and open society. They use it against countries to weaken their popular will and resolve. Do you believe that russia meddled in the 2016 elections . I believe russia has engaged in a very Sophisticated Campaign of subversion to affect our confidence in democratic institutions. They meddled . Including your elections . They used propaganda and disinformation on both sides to support very left groups, to support the very right groups, and so what they want to do was create the kind of tension, vitriol that undermines our confidence in who we are. I talk about any societies that has come under attack from them. There isa similar come under attack from them. There is a similar approach in catalonia in spain. Is this something the president is saying as well . Yes, of course. Hes acknowledging this meddling took place . Yes, publicly. Will you ensure this kind of interference does not happen in the future . Certainly, to the degree we have Agency Control over it but one of the most important things to do is to pull the curtain back on this activity and expose it. There is a feeling that there is nothing like this administration, nothing like this administration, nothing like this president. There is intrigued in this court politics. The intrigue is interesting to people but i have not paid attention to it. It has not affected our work on the National Security council or oui on the National Security council or our ability to serve the president. Would your life be easier if the president stopped tweeting . Aristotle said focus on what you can control. The president will do what he wants to do. And its his way of reaching the American People. Its a communication which is very successful for him. He has quite a number of followers around the world. Myjob is not to worry about twitter. That is ourjob to worry about twitter and what comes out of the president s twitter account. I picked up on the russia staff more than the north korean issue because they seem to be saying if conditions we re they seem to be saying if conditions were right they would talk to north korea. That is where the white house is coming from. This issue of russia, this language, i believe russia, this language, i believe russia is engaged in a Sophisticated Campaign of subversion. I have not heard the president , whatever the National Security adviser says, Say Something quite that clear, and perhaps if he did, and said repeatedly, this russia investigation might go away. If it comes from the top, and as hr mcmaster says, if you reveal what russia has been up to, he could do a lot more, and that has been a complaint from the intelligence agencies that for some reason, whatever reason it is, the president is loaf to criticise russia and is particularly the russian president. The other thing, he says the National Securities strategy sets out the world as letters but i am not convinced when you read that 70 page documents that you get the same tone from the president. There are so tone from the president. There are so many disparities and what he said yesterday and what is in the document that you wonder if he is com pletely document that you wonder if he is completely behind the strategy. Lets get the thoughts of former us defense secretary william cohen, whojoins me now in the studio. Listening to hr mcmaster, what did you take away from that . I did take away the notion that they are prepared to pull back the curtain to look at what russia has been doing. That is the case they should back away from trying to undermine the investigation. The president has come out, i give the president credit for raising that document, it is his now. He has two 0rna everything that is in that. What is interesting is that all of the items in that document, his conduct for the first year in office is contradictory to what is in that document. There is a mismatch between what has been taking place and what is no in the document. For example, respect for the rule of law, the president has done much to undermine the rule of law, attacking cie, the court system, fbi, attacking the investigation and are we seeing it as a witchhunt. There isa we seeing it as a witchhunt. There is a disconnect between what is being said and what is being done. Hopefully the president will most up to match some of the rhetoric with the deeds going forward. Pulling the curtain back on russia will be important but i believe there is no question in our intelligence communities they were not trying to alter and influence the election itself. The president has yet to actually admit that and see it forthrightly. Seeing china might have been behind it, north korea. That is an issue. He could perhaps ta ke that is an issue. He could perhaps take a cue from his National Security adviser. Let us go back to the 70 page document that donald trump gave a speech on yesterday. Do you now understand what the trump doctrine of American Foreign policy is . It appears to be something of a throwback to realpolitik, balanced power politics, the world as we see it. It is ok to look at the world as we see it that we should also have a policy to make the world as we wanted to be. We need to be actively engaged in trying to shape events rather than being held prisoner by those events. That is what is missing in terms of this looking inward, it is saying that we have been taken advantage of, we want the rule of law and diplomacy but they have cut the diplomatic budget by 30 , many positions have not been filled. Matching the deeds with the words that have been uttered, itll be interesting going forward. That have been uttered, itll be interesting going forwardm that have been uttered, itll be interesting going forward. If you we re interesting going forward. If you were to ask people around the world what is the most alarming Foreign Policy trained at the moment they would definitely say north korea. There is no way that pyongyang is going to denuclearise as a precondition for talks. Going to denuclearise as a precondition for talksli going to denuclearise as a precondition for talks. I do not think they will. What we have to do is continue to beef up our defence capability in south korea and also injapan. We capability in south korea and also in japan. We have capability in south korea and also injapan. We have two, unilaterally if we must, bring the north korean economy to its knees, then set the table for how we might go about talking to the North Koreans. It is not alarming, but got my attention, the implication that we are going to do it by force if necessary, whether the chinese are helping, not helping, the russians helping or not, we are going to do it by force, if we have the take those Nuclear Capabilities out. That is something we have to watch carefully. I do not think secretary tillotson will be in favour of that and i doubt if any military adviser would soon let us go and take it militarily. Thank you very much. The train that derailed in Washington State on monday was travelling at twice the speed limit as it came around a corner. 13 of the 1a carriages were thrown from the track, some of them over a bridge and onto rush hour traffic below. The train was carrying 86 passengers as it made its inaugural journey, on a new route from seattle to portland. Three people were killed in the accident. The uks new aircraft carrier, hms queen elizabeth, has sprung a leak. The carrier that was commissioned by the queen earlier this month in portsmouth, has a problem with one of its propeller shafts. The fault was first identified during sea trials. A royal Navy Spokesman said the ship was scheduled for repair and the fault will not prevent it from sailing again early in the new year. Us immigration figures show there have been fewer deportations this year, compared to president 0bamas first year in office. Data suggests that 177,000 fewer migrants were deported, compared to 2009, despite President Trumps tough stance on immigration. Elsewhere, figures suggest unauthorized Border Crossing attempts from mexico have also dropped by nearly 150,000. That is interesting. Border crossings have fallen. The rhetoric, from Donald Trumps perspective is working. The same is true here of brexit, net migration has fallen to the lowest since records began. Seemingly the rhetoric of you are not welcome does work if you want to keep people out. The strange thing is that the number of deportations has fallen when he seems to have given so much leeway to the authorities. That is interesting because there have been figures suggesting that the number of arrests of undocumented immigrants has actually gone up in this year, it mightjust be that people are still in the backlog, they have been arrested, they are waiting for the process, they are waiting for the process, they have not yet been deported. Those figures on emigration as people crossing into america were falling already. Net migration was negative on to the United States across the Mexican Border before President Trump took office which is why many people said, why is emigration such a big deal . The mexican economy is doing better and people are staying at home and getting theirjobs there. President trump is one step closer to getting his first major legislative victory in the form of tax reform. The house of representatives is to vote through the biggest overhaul of the us system in more than 30 years. Next it will go to the senate and then on to the president s desk. Critics say its a giveaway to corporations and the wealthy. But republicans insist it will boost Economic Growth and create jobs. Among them is congressman Francis Rooney from florida and i spoke to him from capitol hill a short time ago. It seems the Republican Party is about to pass a tax bill that 55 of americans say they disapprove of. Why are they doing it . When the 55 of americans that you are talking about realise whats in the tax bill theyll change their mind. The liberal media in the United States has been a bit one sided in how they have described the bill. This is always a Communications Effort and it seems like the democrats have managed to get their Communications Effort more effectively than yours has, then . I think you could probably make that argument. Of course they have the more willing media to support them. The tax bill depends on the idea of boosting american growth. But the tax policy centre, a bipartisan independent group, has come out and said that what is in the bill wont boost american gdp growth enough for this tax bill to pay for itself. You are a fiscal conservative, does adding to the american debt concern you . I would have rather they found a way not to have it be a deficit spend. But i do think that the corporate aspects of this bill will get the economy accelerating and increased investment. As anyone from london knows better than anyone capital goes where it is treated best. We have not been treating capital very well in the United States for some time, as opposed to londons financial centre. We need to get the tax rate down so corporations are going to want to be here, invest their capital here. And corporations are clearly very happy with this bill, as are wealthier americans who are looking at a very big tax cut. But what about the argument that this tax bill does very little for poorer and lower working class americans, lower income people . If you want to have jobs you have got to have Capital Investment which means the people you havejust been talking about have to be wanting to invest. That is one side. But the other thing is, if you look at the rates, this bill is a tax cut for virtually everyone across the spectrum, and a larger percentage tax cut for those at the bottom of the spectrum. Right, but you are asking corporations to reinvest in the country and to produce jobs, but even the treasury secretary, when he asked a group of american ceos what they were going to do with this tax windfall, are you going to invest back into the economy and invest into job creation, they did not put their hands up. They said, no, they were going to return it to their shareholders. I saw that question and answer period. I am not so sure that is actually right. Inevitably when Corporate Tax rates are lower then more capitalflows back into the United States or whatever country does it. We saw that when ireland lowered their tax rates. I am confident we will have more capital coming in. Ultimately that capital will get invested. The other aspect is the immediate deduction of capital goods acquisitions. Let me just ask you about the way this bill was done. Handwritten notes on the Senate Version of the bill. Votes taken at two or three oclock in the morning. If you want the American People to understand what is in this bill is that the best way to do it . No. We always used to tell our kids, nothing good happens after midnight, and i think that is probably true for a lot of different kinds of things. It would be better to have a more orderly process but i have to say, the end product is pretty good. Thank you very much. Keep it in the daytime, kids. Thank you very much. Live to capitol hill. Every expectation that this tax bill is going to go through the house, then it goes to the senate, then to the president s desk, he wants to sign it before christmas, he says americans will get a big tax reduction. It is politically a big gift at the moment to the Republican Party but the nature of this tax bill seems so skewed in favour of wealthy americans rather than less well off americans that some democrats are thinking if they pass that this could come back to haunt them and help us in future elections. It is a gamble if you give corporations money do they create enough growth to pay for the tax cuts, that is the gamble. Does trickle down economics work . Plenty of economists will point to it working, plenty of economists will point to is not working. We have at republican senators saying they prefer republican senators saying they p refer to republican senators saying they prefer to believe the economists who say that it will boost growth and the economy and jobs as well. We will start to see what it does just before the mid term elections. For most people, christmas just aint christmas without the traditional roast turkey. In the uk it is still the most popular thing to serve on the 25th and often for several days afterwards archaeologists in devon believe they have unearthed the oldest turkey bones ever discovered in the uk dating back almost 500 years old. Jon kay has the story. A traditional turkey dinner with all the trimmings, but it seems theyve been gobbling it up here in devon for much longer than anybody realised. At exeter university, a surprise discovery. At first i wasnt sure because it looks like a giant chicken. In a pile of ancient animal remains, found here in the 80s, two mysterious thigh bones and a wing. Archeologists have now established theyre from an american species of turkey nearly 500 years ago, believed to be the oldest ever found in britain. I started knocking on doors and showing offjust how excited i was by actually telling other people, look what i found. But, yes, so it is very nice and its really great for a zoo archeologist to actually have this connection with history. Weve got a plate and a bowl. The bones could be dated because they were found with a pile of washing up crockery from a grand feast in the early 1500s, which is when the first turkeys arrived here. These were an exotic bird, brand new into the country. You know, people wouldnt have heard of it. What did it taste like . You know, what is this giant bird . The first turkeys are said to have been imported by the explorer William Strickland in the 1520s after he bought six from some native americans. Well, strickland is said to have sold his birds for tuppence each. Five centuries later, turkeys are rather bigger business, 10 million of them due to be sold in britain just over christmas. Off we go then, turkeys. This devon farmer wonders if the bones found down the road might be from those original birds. Potentially these, in some way, are direct descendants of the ones that arrived, and here they are back in devon. So thats quite nice. In what else but a sandwich box, the turkey bones have now been taken to the city museum to go on display after christmas dinner. Jon kay, bbc news, exeter. We had turkey for thanksgiving. I am going to do goose. If i am not around after christmas that will be because the goose burnt my house down. Germany has marked the First Anniversary of the terror attack in which 12 people were killed. Angela merkel was among those attending the ceremony. Authorities say mistakes we re ceremony. Authorities say mistakes were made including bills being sent to the families for the cost of autopsies. Angela merkel said it was time to connect the things that went from. 12 people were killed in that attack on the christmas market. 70 people were injured. The authorities we re people were injured. The authorities were criticised at the time for security feelings. Let us go back to capitol hill, we can get those live pictures from the house of representatives. They are voting on that republican tax bill at the moment. At the moment 212 republicans in favour, ten have faltered against. That is interesting to see who has fought against. Democrats, 182. Every expectation that it will pass, pretty much along party lines, they are desperate to get this done, they have not had a big piece of legislation, and they cannot wrap up this year with nothing done. President trump would not accept it. Plenty of applause. It looks like it is going through. When does that go to the senate . Later today. We are expecting to go and if you average time. You will be in bed. I will be in bed. Do text when it goes through. This is beyond 100 days from the bbc. Coming up for viewers on the bbc news channel and bbc world news the superagers living longer and healthier and the drugs the might help the rest of us do the same. And the stories behind these faces and flags. We speak to our china and europe editors on the year that was and the one thats still to come. Thats next. After what was a foggy start in a few places some of us got to enjoy some sunshine today. It was beautiful for our weather watcher in stockton on tees but i suspect this scene from starling is more representative of what most of us will see over the next few days. Cloud is no coming from the atlantic. I head of that mile are being drawn from the south west providing cloudy conditions through this evening. Misty and murky conditions over hills in the west. A spot of drizzle as well. Not as much fog as we saw last night in east anglia and the south east. The apache band of rain across central areas of the country by morning with some clear skies. Patchy band of rain across central areas of the country. To the north of that a better chance of early sunshine. Easy in the far north. Northern areas with the best chance of sunny breaks through the day. This weather fronts dragging its heels across Northern England and north wales. To the south of that, cloudy conditions. Temperatures for many getting into double figures. 0ur week whether fa ns double figures. 0ur week whether fans will still be with us on thursday, journeying further north east. Misty and murky conditions. Best chance of brightness across the north east of scotland. Here it will be chilly, but still mild ear. The weather fronts will get squeezed out by this area of High Pressure which tries to dominate our weather on friday. There could be some Zelda Perkins rain. A lot of cloud around. Some there could be some patchy rain. As we head towards christmas it will stay miles. There will be rain at times particularly in the north. This is beyond one hundred days, with me katty kay in washington Christian Frasers in london. Our top stories. Donald trumps National Security advisor hr mcmaster tells the bbc the us wants a solution on north korea with, or without, pyongyangs cooperation. Lawmakers have just passed the biggest overhaul of the us tax system in more than three decades but not without fierce opposition. Coming up in the next half hour. Putting the ageing process on ice the drug which could help us live longer and healthier. The year that was for our china and europe editors theyre with us to help make sense of 2017 and the stories keeping them busy into the new year. Let us know your thoughts by using the hashtag beyond 0ne hundred days. In her first broadcast interview, a former colleague of hollywood producer Harvey Weinstein has told the bbc, how she was warned about his behaviour and how she went on to warn other women that he could behave in an inappropriate manner. But Zelda Perkins says matters escalated after he sexually assaulted a colleague and she accused him of attempted rape. Mr weinstein denies all allegations of non consensual sex. 0ur entertainment correspondent, colin paterson, has the story. To put it into context this was 19 yea rs to put it into context this was 19 years ago, 1988. Harvey weinstein was at the peak of his powers. Just about to release shakespeare in love which would win him an oscar. Bella s personal assistant then in the uk Zelda Perkins and was then 2k and she quit. She explained that she endured a number of years of Sexual Harassment but then came the final straw. It came to a head when he sexually assaulted, attempted rape on a colleague . Yes, we were at the Venice Film Festival and he tried to rape her. What did you do . She was distressed. She was terrified of the consequence. I tried to calm her for about half an hour. Then i went straight downstairs to where Harvey Weinstein was having a business meeting on the terrace and told him he needed to come with me right away. For me to have broken into a meeting like that was unusual and he did not question me, he came with me straightaway because he knew why i was angry. So you accused him . Yes. He denied it . Yes. He said nothing had happened and he swore on the life of his wife and children which was his get out ofjail card. He used that quite a lot. Now the women secured legal representation and they were hoping to bring down weinstein by revealing his behaviour to disney owned his company but their lawyers said that was not a realistic option and the only option was a damages agreement. That included the creation of a complaints procedure and therapy for Harvey Weinstein. It is not known if these stipulations were carried out. Zelda perkins signed a non disclosure agreement and received a sum of £125,000. She calls for britain to follow the example of a number of us states and end the practice of allowing sexual assaults to be hidden behind non disclosure agreements. A spokesperson for Harvey Weinstein says he unequivocally denies any allegations of non consensual sex. A good point there that these alleged assaults are being hidden behind nondisclosure agreements. This is not the first case weve seen this is not the first case weve seen this. There was one covered by cnn at the weekend about a fox contributor who had signed a nondisclosure agreement with fox news and had effectively been silenced and had not been able to get work since. Yesterday has been a lot of pushback against these nondisclosure agreements since the weinstein case because they perpetuate what women say is a culture of silence and also means that women cannot warn other women about predators. So here in the us women are saying about predators. So here in the us women are saying that theyre going to break nondisclosure agreements. Time magazine called them silence breakers. What sort of trade deal does the uk want with the European Union . The debate in britain is split right now between those who want the uk to remain close to the rules of the Single Market and those who want the uk to go its own way, with the freedom to sign its own trade deals. The trouble is you cant have it both ways. Today theresa may held talks on the future relationship with her full cabinet. 25 ministers were each given an opportunity to speak. It took an hour and 45 minutes to get around the table. At the end, the Prime Minister gave very little away. What she wants, she says, is a bespoke deal, not a norway, not a canada, but a deal which secures a full trading relationship with the eu. Lord Malloch Brown is a former Foreign Office minister, he was the former deputy secretary general of the un, and he is with us in the studio. You are taking on a new role in coordinating the pro remain groups, what is it that you want . Neither of the above neither norway or canada. I want to reverse brexit and take a second decision. The more we learn about brexit the more we see that essentially we were mis sold something at the beginning of this, the Financial Times reported this week that the cost already to the british economy is pretty much the equivalent of the £350 million a week than we thought we were going to save and put into the nhs if we left. So the economic costs are mounting, the risks are huge, our standing with friends and allies is in real doubt. Ive just standing with friends and allies is in real doubt. Ivejust come back from germany this morning and frankly people are completely perplexed by this. Are the risks huge because i read this evening that the uk has topped the four best countries for business, factory orders are booming for next year because of the cheap pound sterling. And the other thing that remain are still unexplained is what kind of europe they want to belong to, is it a europe, a United States of europe because that seems to be the direction it is heading in. Well versed on the facts if you like, there is a little bit of manufacturing boom because of the depreciation of the pound, that same depreciation of the pound, that same depreciation though that makes food more expensive in the shops, holidays more expensive abroad. And which ultimately, the parts going into manufacturing, that cost will go into manufacturing, that cost will 9 up into manufacturing, that cost will go up as well so it is short term shotin go up as well so it is short term shot in the arm. And what kind of europe, i think it is pretty clear that the uk is always going to be in the kind of outer rim of europe, not pa rt the kind of outer rim of europe, not part of the euro, we will always be sceptical about the integration ambitions of the french or whatever. But the fact is it is a comfortable place to be, many other europeans feel the same way. It is a pity that we have separated ourselves from them and lost her voice to influence them and lost her voice to influence the debate inside europe. So you are spent your whole career working in organisations like the un and British Government promoting democratic processes and good governance. Are you at all concerned that by trying to organise people in the roman camp against this referendum that there might be a dangerous president of undermining democratic processes because after all the referendum was taken and the british people voted and we should respect that . Democracy is about continuing not a final for every choice. We have a referendum in the 19705 choice. We have a referendum in the 1970s after all which said let us be in. So if that was the last word why did we have another. And again the fa ct did we have another. And again the fact is in the same way that we change government through the ballot box when we decide that the government has let us down, those who made the case for brexit are in the process of letting us down. All the process of letting us down. All the claims are being exposed as wrong, and we are simply not going to get the glories of getting our ca ke to get the glories of getting our cake and eating it as the promised wanted. Were not going to have a trade deal without any costs. Were not going to have alignment of regulations with europe unless that also governs trade with the rest of the world. And we will not have any of that except as Boris Johnson calls it, as a vassal state because we re calls it, as a vassal state because were no longer going to be a rule maker but i will take. We are making ourselves or at risk of making ourselves or at risk of making ourselves a colony of europe and not a sovereign state member of europe. The voices are allowed on either side. We will see where the chips fall in the new year. Thank you. Reports in from mexico, a bus carrying tourists from us cruise ship has crashed killing at least 12 people. It happened on a highway and visitors bought 31 people were on board the bus at the time. They are perennial questions how do we look younger, live longer, go faster, be stronger . Now, scientists here in the United States are predicting that there will soon be drugs that could help delay ageing. In the second of his special reports, our medical correspondent, fergus walsh travels to San Francisco and new york to meet the so called superagers who could hold the key and hopefully share with us all the secrets of a long and healthier life. New york public library, one of the citys grandest buildings, which has one of the citys oldest employees. Hilda jaffe is still going strong at 95, so whats her secret to a long life . Pick your parents, it really is. Its got to be genetic because both my parents lived long. Good morning, fergus, im glad you could meet me here in this absolutely beautiful room. Hilda gives tours of this Historic Building when shes not at the theatre, music concerts, opera or her two book clubs. I dont exercise, i walk, i walk a lot. If i had to give anybody advice i would say, just keep moving. Samples of hildas dna are stored in this freezer in the bronx, part of a study into longevity. They found only one in 10,000 people has protective superager genes, but say drugs might be able to help the rest of us. Metformin is an old, cheap diabetes drug, but a major trial is planned to see if it can delay ageing. I can get you 690 of those for 60. Scientists here believe it may slow the biological processes that trigger key diseases. We have data in humans that metformin would delay cardiovascular disease and will delay diabetes and is associated with less cancer, and seems to delay alzheimers or cognitive decline in people. Ageing is an inevitable process which begins as we reach adulthood and continues through the decades as our muscles, bones and organs gradually wear out. This Tai Chi Group in San Francisco show that we can delay that decline, it helps with balance, core strength and provides a social network. It makes me feel so young, i have so much fun. I feel like im in the kindergarten of the universe. My mother lived to 103. I dont desire to live that long, but i want to be as healthy as i can, as long as i can. Thats an ambition we can all share. Imagine a future where it didnt hurt to get old, where ourjoints didnt wear out . It would have a huge impact on our quality of life as we age. This Biotech Company in california has developed a drug to counter one of the key diseases of ageing, osteoarthritis. Human trials of this experimental compound should begin next year. This is an area of the cartilage that is now diseased. You can see the cartilage is damaged. It works by clearing cells which build up in the kneejoint, which maybe a trigger for the painful condition. A single injection that we believe and hope will alleviate their pain and begin the restorative process in their knee to perhaps at least halt, regress and even completely repair the knee in the end is what our wildest hopes would imagine. That would mean more people could age like hilda, free of aches and pains and independent well into their 90s. Fergus walsh, bbc news, new york. Ifailed to get i failed to get you a Christmas Present so that is it, longevity pills. This is beyond one hundred days. Still to come what do you make of 2017 . Well be putting that to our china and europe editors as they reflect on the year that was and look ahead to the one thats coming. Here in the uk, bomb disposal officers have raided a house in derbyshire after a man was arrested on suspicion of plotting terror attacks. In totalfour men have been detained after raids in sheffield and chesterfield. 0ur correspondent, danny savage, reports. On a terraced street in chesterfield today, Army Bomb Disposal experts were looking for explosives. They have been here for hours. Counter terrorism officers arrested a 31 year old man here this morning. In the predawn darkness, armed police were pictured guarding the scene as the raid took place. At the edge of the cordon, people evacuated from their homes couldnt believe what was happening in their streets. They come banging on the door saying, you need to evacuate. My grandad refused to leave the house. Hes still in there now. The only one on the street. And they said, its for your own safety, bomb disposal are here. They made everyone else leave apart from him. Arrests were made elsewhere too, as police took action against an alleged islamist terror plot against the uk that could have come to fruition over christmas. Although the most obvious activity was in chesterfield, about 15 miles away in the burngreave area of sheffield, two other men were arrested. A business was raided, and another man was arrested in meersbrook, where local people heard stun grenades being used. We were woken up at about 5 30 by a really, really loud bang. Initially we did think that somebody had crashed outside our house. So we were looking outside, and all we could see were Police Officers in riot gear. They were storming a house across the road from us. There was lots of running about, lots of shouting. This is the Fatima Community centre in sheffield, where two of the detained men were arrested in bedsits adjoining the centre. These were co ordinated Counter Terrorism raids, which may have stopped a plot timed to coincide with the christmas holidays. 2017 has been a very busy year around the world. This week were going to pick the brains of the bbcs top editors to get the key issues from their different areas of the globe. Were starting with europe and china. Here in europe, brexit rolls on. So doesjeremy corbyn. Populism was defeated in france, macron is the new emperor. But in germany the afd are in the bundestag. And Angela Merkel is wobbling. In china, xijinping becomes the most powerful leader since mao. Well be speaking to Carrie Gracie our china editor and our europe editor, katya adler injust a moment but first, this gives you a flavour of what theyve been covering this year. And where is Carles Puigdemont and after he declared the new catalan republic, when he left barcelona this weekend and came here to the medieval town of tirana. His hometown and also known as the heartland of catalan nationalism. This is the art of the deal according to trump, it says you cant be imaginative if you have too much structure. But this is the art of war, essential reading for chinese statesman, it says know your enemy, know yourself. The supreme victory is to subdue your enemy without a fight. Well katya and carrie are with us now. The perception from this side of the atla ntic the perception from this side of the atlantic is it has been a very good yearfor atlantic is it has been a very good year for xi atlantic is it has been a very good yearfor xijinping, atlantic is it has been a very good yearforxijinping, he has atlantic is it has been a very good yearfor xijinping, he has amassed a lot of barrelled through the congress and china is expanding and possibly stepping into the space that america is living in terms of Global Leadership. How is it seen from china . Exactly like that, i think many chinese feel that President Trump has contributed not to making America Great again but making china great again over the past year. And that of course is the big theme of xijinping, the great rejuvenation of the chinese people. And i know you have been talking about the Strategic Security review in the United States and this discussion about seeing china as a rival rather than a cooperative power. But for the past year suddenly the United States has provided an opportunity, the arrival of trump provided an opportunity for president xijinping because of trump provided an opportunity for president xi jinping because with him pulling back on Climate Change and on big trade agreements for the asia pacific, that has given xi jinping the opportunity to step into those shoes and present himself as the mature and responsible statesman. I can also imagine that the chinese are a bit confused about what the american president thinks of their leader. Lets listen to some of the conflicting things he has said. We cannot continue to allow china to break our country. They have ta ken allow china to break our country. They have taken our money, they have taken our jobs. China they have taken our money, they have taken ourjobs. China is a currency manipulator. America has lost 70,000 factories. Since china entered the world trade organisation. When you look at china, when you look at every country, every trade deal we have, it is horrible. It is going to be only america first. Who can blame a country for being able to take advantage of another country. For the benefit of its citizens. I give china great credit. Im confused and i have been following this story nonstop for the past year. It is interesting because the chinese are not confused, they see this as a cycle, as an electoral cycle on the us, there are quite cynical about that and also they see it as a historical cycle as in every time a us president comes into power, certainly over the past 15, 16 yea rs, certainly over the past 15, 16 years, they have said were to take china as a big strategic issue. For george w bush, his administration we re george w bush, his administration were all set to stay the same thing is roughly that we had donald trump saying yesterday but then september the 11th happened and the United States needed china in other ways. 2009, barack 0bama, the financial crisis around the globe. And all kinds of domestic political problems as well as problems in the middle east. So then he got distracted from that. And now President Trump, he wa nted that. And now President Trump, he wanted to come into power and to get tough with china but then he needed them on north korea and yet again them on north korea and yet again the rhetoric has been deluded. I think the thing the chinese would look at now is the message yesterday that this is arrival, a revisionist power and economic, military and ideological terms, hostile to us values. They will want to know now thatis values. They will want to know now that is just rhetoric or if it is for real. It seems that everybody is trying to work out how to play donald trump. The germans and french have gone and it in different ways. When it comes to donald trump, looking at the eu you have 28 Member States and looking at him and really wondering always what is going to do next. Trade is on the minds of the eu but also security. Because since the end of World War Ii Europe has depended on the us for its global security. If you look at Angela Merkel she is someone who always has her eye on domestic issues yes and especially at the moment but always on the bigger picture, someone who grew up in east germany and is very much aware of its nazi past, looking at fatima putin as knowing that he would like to weaken the unity of the eu. She looks at donald trump, he took quite a hit when campaigning for president at the eu as well. Worried about his commitment to nato, his personal commitment to nato, his personal commitment to nato and this worries france as much as germany as well. And every other single European Union state. They do not know what to make of him, they do believe hes here to stay and the thinking in brussels is that he could be elected for a second term so could be elected for a second term so they are not to alienate him and criticise him and they are taking steps within the eu to try to bolster their own defence a little bit more and notjust rely on the us. Yet i get the impression that emanuel macron sees an opportunity here on Climate Change and perhaps iran as well, and he is worked out that if you soothe his ego you can do an awful lot with donald trump. There was that famous handshake when emanuel macron matt donald trump and he was going to be the one to really shake that had family. I think what will be interesting next year is whether emanuel macron falls into the same unfortunate boxers barack 0bama at the time, you remember he was awarded the Nobel Peace Prize before he really achieved anything. And barack 0bama in that way peaked too early in global opinion. Is it the same with emanuel macron, you described in there as the new emperor of europe. That title was given previously to Angela Merkel but her crown is now slipping. Certainly she was uncomfortable with the idea that she might take over as the idea that she might take over as the Global Leader in moral values if you like after barack 0bama stepped down. He chose his last visit as us president to come to berlin to see her. But germany and Angela Merkel have gone through a very uncomfortable phase, too much in the limelight as leaders given though economically and politically it is still the strongest country in europe. But emanuel macron is not so bashful. But how he lives up to that reputation will have to see. And they gave a joint press conference actually on friday, i think they may beware about his comments about who has the upper hand at the moment. Briefly, the big issue for china next year . I think the key issue for china at the end of the day is whether it solves its problem at home because the reform is now a0 yea rs old home because the reform is now a0 years old in china, they have huge contradictory problems in the economy going on with enormous leverage with poverty, with pollution, they have a property tax effectively and no pensions that work. So xijinping needs effectively and no pensions that work. So xi jinping needs to use this new power he has to resolve the key domestic problems which will provide the launch pad to that superpower status that he wants. We will be watching all of those countries during the course of the next year, thank you very much. And on tomorrows show brexit, trump, may and moscow the year that was, and the year that could be according to our uk political editor, laura kuenssberg, and north america editor, jon sopel. Thats tomorrow on beyond 0ne hundred days, from 1900 gmt. We look forward to that tomorrow. Coming up next on bbc world news ros atkins is here with 0utside source and for viewers in the uk well have the latest headlines from reeta chakrabarti. For now from katty kay in washington and me Christian Fraser in london goodbye. After what was a foggy start in a few places some of us got to enjoy some sunshine today. It was beautiful for our weather watcher in stockton on tees but i suspect this scene from sterling is more representative of what most of us will see over the next few days. Cloud is now coming from the atlantic. Ahead of that mild air being drawn from the south west providing cloudy conditions through this evening. Misty and murky conditions over hills in the west. A spot of drizzle as well. Not as much fog as we saw last night in east anglia and the south east. A patchy band of rain across central areas of the country by morning with some clear skies. To the north of that a better chance of early sunshine. Northern areas with the best chance of sunny breaks through the day. This weather front dragging its heels across Northern England and north wales. To the south of that, cloudy conditions. Temperatures for many getting into double figures. A weak weather front will still be with us on thursday, journeying further north east. Misty and murky conditions. Best chance of brightness across the north east of scotland. Here it will be chilly, but still milder. The weather fronts will get squeezed out by this area of High Pressure which tries to dominate our weather on friday. There could be some patchy rain. A lot of cloud around. As we head towards christmas it will stay mild. Some it will stay mild. Rain and times especially in the some rain and times especially in the north. This is bbc news. Im reeta chakrabarti. The headlines at 20 00 police say theyve disrupted an alleged terror plot, that could have been carried out over christmas. Four men have been arrested in sheffield and chesterfield. Jailed for 20 years the man who threw acid into a crowded nightclub in east london. Social Media Companies are taken to task by mps, as theyre accused of not doing enough to tackle hate crime. Fears for the future of the retailer toys r us, as a rescue plan is put to its creditors. And in the next hour us accident investigators reveal a passenger train was travelling at twice the speed limit before it crashed in Washington State. Three people died, and more than 70 others were injured, when the amtrak express came off the rails during the morning rush hour. And well be hearing about the worlds first vending machine for the homeless a nottingham based innovation