CHOP researchers engineer stable, universal MHC-I molecules in a shorter timeframe

Class I major histocompatibility complex (MHC-I) proteins play an essential role in the immune system of all jawed vertebrates. The MHC-I displays peptide fragments of proteins from within the cell on the cell surface, "presenting" them to the immune system, which is constantly scanning the body for foreign or toxic antigens.

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University Of Pennsylvania ,Pennsylvania ,United States ,Fox Chase Cancer Center ,Philadelphia ,Michaelc Young ,George Burslem ,Lily Ramsey ,Nikolaosg Sgourakis ,Yi Sun ,Claireh Woodward ,Sgourakis Lab ,Proceedings Of The National Academy Sciences ,National Academy ,Senior Author ,Associate Professor ,Genomic Medicine ,Antigen ,Dancer ,Fell ,Children ,Hospital ,Immune Response ,Immune System ,Immunotherapy ,Olecule ,Eptides ,Research ,Vaccine ,