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Keto Fuel for the Heart May Drive New CVD Therapies

email article The same ketones involved in diabetic ketoacidosis could have a protective role in cardiovascular disease (CVD), animal and human studies suggested. Emerging evidence points to several cardiovascular benefits to these metabolites, according to B. Daan Westenbrink, MD, PhD, of University Medical Center Groningen in the Netherlands, and colleagues: Fuel for cardiac energetics: ketones act as ancillary fuel for the failing heart given that they require less oxygen per molecule of ATP generated Pleiotropic effects on other cellular processes: ketones are linked to improved endothelial function, protection from oxidative stress, direct targeting of inflammation, and slowdown of pathological cardiac remodeling

Give the heart a ketone? It may be beneficial

There is growing evidence that ketone bodies may be beneficial to heart disease patients regardless of the method of delivery used to increase ketone delivery to the heart. A Journal of the American College of Cardiology review paper examines emerging evidence regarding ketone bodies effects on the heart and the potential for ketone therapy as a cardiovascular intervention in heart disease patients.

Intravacc announces formation of Scientific Advisory Board

Intravacc announces formation of Scientific Advisory Board News provided by Share this article BILTHOVEN, the Netherlands, Feb. 23, 2021 /PRNewswire/   Intravacc, a world leader in translational research and development of vaccines, today announced the formation of a Scientific Advisory Board ( SAB ), chaired by Intravacc s Chief Scientific Officer Virgil Schijns and further comprising scientific leaders in the fields of vaccinology, infectious diseases and oncology. Intravacc s SAB will be consulted to help define the proper vaccine strategies and solutions to establish an impact on public health supported by convincing scientific clinical data. The SAB will also advise on the company s research strategy and approaches to optimize therapy effectiveness and added value.

3D models enable custom treatment of complex acetabular fractures

A team of researchers led by Dr. Frank Ijpma, PhD, of the University Medical Center Groningen in the Netherlands shared results from a case series of 10 acetabular fracture patients who were treated using a fast-track surgical procedure. The group found that their approach, which involves 3D virtual surgical planning and manufacturing patient-specific osteosynthesis plates and drilling guides, was feasible and yielded good clinical outcomes. Fast-track personalized surgical treatment could open a new era for the treatment of complex injuries, the authors wrote. Optimally reconstructing the articular surface during acetabular fracture surgery lowers the risk of osteoarthritis and subsequent need for total hip arthroplasty, according to the researchers.

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