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The effect of Omicron breakthrough infection on the magnitude and breadth of serum neutralizing activity and memory B cells among BNT162b2 vaccinees

Researchers evaluated the impact of breakthrough infections with SARS-CoV-2 Omicron BA.1 sublineage on SARS-CoV-2 variants of concern neutralization and memory B lymphocytes formation among BNT162b2 vaccinees.
Delta Rbds Science Immunology Coronavirus Disease Covid 19 B Cell B Lymphocyte Ibonucleic Acid

Trial of peptide-centered SARS-CoV-2 T-cell activator in B-cell deficient individuals

A recent phase 1/2 study under review at the Nature Portfolio journal and posted to theย Research Square* preprint server demonstrated that a peptide-centered severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) T-cell activator, CoVac-1, was efficient in B-cell deficient people.
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Study suggests that recall of B cell memory may depend on relative locations of prime and boost immunization

A new study investigated whether a specific population of local Bmem cells in the proximal LNs produce secondary GC responses that are different from those at distal sites and if the location in humoral immunity is relevant only to nonlymphoid tissues.
Kateryna Kon Shutterstock While Bmem Science Immunology Influenza Hemagglutinin B Cell Immune System

3rd dose of COVID mRNA vaccine expands memory and capacity of immune system to combat Omicron

Researchers from the United States have now found that the immune recall induced by a two-dose primary series of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination after an initial natural infection highly improves the longevity of the antibodies as well as induces an enhanced breadth of protection across the SARS-CoV-2 variants.
United States Aimee Molineux Namita Mitra Kruskal Wallis Namita Mitramay Billion Photos

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