Page 40 - Cell Stem News Today

As more Americans anxiously wait their turn to get the COVID-19 vaccine, people are discovering that smokers are one of the priority groups for vaccination. Some don’t agree with the guidance and have expressed their frustrations on social media. But health experts say the rationale is clear.  “I could see why people would feel as if that would be unfair but people who are smokers are in general at higher risk for getting sicker when they develop COVID-19,” said Dr. Samuel Kim, a thor...

 E-Mail IMAGE: An image showing a blood vessel in fat tissue, surrounded by fat progenitor cells (in green). view more  Credit: UT Southwestern Medical Center DALLAS - Feb. 3, 2021 - Gaining more fat cells is probably not what most people want, although that might be exactly what they need to fight off diabetes and other diseases. How and where the body can add fat cells has remained a mystery - but two new studies from UT Southwestern provide answers on the way this process works. Th...

Stem cell study illuminates cause of dilated cardiomyopathy (DCM) 2 A study using stem cells has revealed that DCM-causing mutations in LMNA disrupt the organisation of DNA in the nucleus of heart muscle cells. Scientists report they have uncovered the molecular causes of a congenital form of dilated cardiomyopathy (DCM), an often-fatal heart disorder. The study was conducted at the Perelman School of Medicine at the University of Pennsylvania, US.  This inherited form of DCM is one of multip...

 E-Mail PHILADELPHIA--Scientists in the Perelman School of Medicine at the University of Pennsylvania have uncovered the molecular causes of a congenital form of dilated cardiomyopathy (DCM), an often-fatal heart disorder. This inherited form of DCM -- which affects at least several thousand people in the United States at any one time and often causes sudden death or progressive heart failure -- is one of multiple congenital disorders known to be caused by inherited mutations in a gene called ...

In their experiments, researchers targeted IRF4, a gene which allows myeloma stem cells and tumors to multiply and survive.

Designer DNA Helps Treat Multiple Myeloma in Mice by Angela Mohan on  January 21, 2021 at 12:20 PM Targeted approach helps to treat myeloma by silencing IRF4, a gene that allows myeloma stem cells and tumor cells to proliferate and survive. Past studies have shown that high IRF4 levels are associated with lower overall survival rates for patients with the disease, as per the team of researchers at University of California San Diego School of Medicine and Ionis Pharmaceuticals...

Antisense Oligo Targets IRF4 Gene to Treat Multiple Myeloma Source: OGphoto/Getty Images January 21, 2021 Scientists at the University of California San Diego School of Medicine and Ionis Pharmaceuticals are taking a new, targeted approach to the treatment of myeloma: silencing IRF4, a gene that allows myeloma stem cells and tumor cells to proliferate and survive. Past studies have shown that high IRF4 levels are associated with lower overall survival rates for patients with the disease. Cell ...

Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another. That's in part because cancer stem cells drive the disease -- cells that continually self-renew. If a therapy can't completely destroy these malignant stem cells, the cancer is likely to keep coming back.

 E-Mail Many patients with multiple myeloma, a type of blood cancer, eventually develop resistance to one treatment after another. Thats in part because cancer stem cells drive the disease -- cells that continually self-renew. If a therapy cant completely destroy these malignant stem cells, the cancer is likely to keep coming back. Researchers at University of California San Diego School of Medicine and Ionis Pharmaceuticals are taking a new, targeted approach to myeloma treatment -- silencing...

Ionis teamed up with researchers at the University of California, San Diego to inhibit the gene IRF4 in multiple myeloma using an antisense oligonucleotide. The drug, called ION251, significantly cut levels of multiple myeloma cells and enhanced survival in mouse models of the disease.