Page 39 - Cell Stem News Today

Credit: UT Southwestern Medical Center Using genetic engineering, researchers at UT Southwestern and Indiana University have reprogrammed scar-forming cells in mouse spinal cords to create new nerve cells, spurring recovery after spinal cord injury. The findings, published online today in Cell Stem Cell, could offer hope for the hundreds of thousands of people worldwide who suffer a spinal cord injury each year. Cells in some body tissues proliferate after injury, replacing dead or damaged cel...

Credit: IU School of Medicine Researchers at Indiana University School of Medicine have successfully reprogrammed a glial cell type in the central nervous system into new neurons to promote recovery after spinal cord injury--revealing an untapped potential to leverage the cell for regenerative medicine. The group of investigators published their findings March 5 in Cell Stem Cell. This is the first time scientists have reported modifying a NG2 glia--a type of supporting cell in the central ner...

 E-Mail There is no stronger risk factor for cancer than age. At the time of diagnosis, the median age of patients across all cancers is 66. That moment, however, is the culmination of years of clandestine tumor growth, and the answer to an important question has thus far remained elusive: When does a cancer first arise? At least in some cases, the original cancer-causing mutation could have appeared as long as 40 years ago, according to a new study by researchers at Harvard Medical School an...

Cloning Fast Facts Here’s some background information about cloning, a process of creating an identical copy of an original. Facts Reproductive Cloning is the process of making a full living copy of an organism. Reproductive cloning of animals transplants nuclei from body cells into eggs that have had their nucleus removed. That egg is then stimulated to divide using an electrical charge and is implanted into the uterus of a female. Therapeutic Cloning is the process where nuclear transplanta...

Cloning Fast Facts Here’s some background information about cloning, a process of creating an identical copy of an original. Facts Reproductive Cloning is the process of making a full living copy of an organism. Reproductive cloning of animals transplants nuclei from body cells into eggs that have had their nucleus removed. That egg is then stimulated to divide using an electrical charge and is implanted into the uterus of a female. Therapeutic Cloning is the process where nuclear transplanta...

Management Team Mesoblast has a highly experienced management team made up of individuals who have held senior positions in international pharmaceutical and... | February 16, 2021

Stem cell study illuminates the cause of an inherited heart disorder Scientists in the Perelman School of Medicine have uncovered the molecular causes of a congenital form of dilated cardiomyopathy (DCM), an often-fatal heart disorder. Pictured, an iPSC-cardiomyocyte harboring an LMNA mutation. Researchers at Penn studied how mutations in LMNA impact how DNA is organized in the cell. (Image: Penn Medicine News) This inherited form of DCM—which affects at least se...

 E-Mail (New York, NY) February 10, 2021 - A research team led by the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) has built the first cellular model to depict the evolution of acute myeloid leukemia (AML), from its early to late stages. By using gene editing technologies to alter genes that make cells malignant, the team was able to identify potential therapeutic targets for early disease stages. The study was reported in the journal Cell Stem Cell in February. The therapeutic...

New York– The gene that increases the risk of Alzheimer’s disease can increase a person’s susceptibility to and severity of Covid-19, researchers say. The study, published in journal ‘Cell Stem Cell’, suggests that the gene — ApoE4 — showed a higher susceptibility to SARS-CoV-2 infection. “Our study provides a causal link between the Alzheimer’s disease risk factor ApoE4 and Covid-19 and explains why some (e.g., ApoE4 carriers) but not all Covid-19 patients exhibit neurologica...

 E-Mail A City of Hope-led research team found that the same gene that increases the risk for Alzheimers disease, ApoE4, can increase the susceptibility to and severity of COVID-19. "Our study provides a causal link between the Alzheimers disease risk factor ApoE4 and COVID-19 and explains why some (e.g., ApoE4 carriers) but not all COVID-19 patients exhibit neurological manifestations" said Yanhong Shi, Ph.D., director of the Division of Stem Cell Biology at City of Hope and co-corresponding...