Page 38 - Cell Stem News Today

Dutch researchers have an ambitious vision for their organoid.

Usually, no one wants things to end in tears — unless they are the experts who have successfully grown miniature human tear glands in the lab that cry like real eyes.  The team from the Netherlands grew the organoids to investigate how certain cells in tear glands allow us to keep our eyes clear and lubricated, as well as get all weepy. Located in the upper part of the eye socket, tear glands secrete tear fluid, which is made of water, proteins, lipids and electrolytes. However, tear glands ...

Loading video... Credit: Marie Bannier-Hélaouët, Hubrecht Institute Stem-cell-derived organoids that swell up with tears could shed light on the biology of crying and dry-eye disease, suggests a study publishing March 16 in the journal Cell Stem Cell. Although regenerative therapies using human tear-gland organoids will not be possible anytime soon, these researchers have demonstrated that the organoids can engraft, integrate, and produce mature tear products upon transplantation into mouse ...

Using new organoid technology, scientists have grown miniature tear glands that actually cry. They hope the organic models can be used to develop treatments for tear gland disorders, and eventually for transplants.

A new study yields fascinating results that promise a possible solution to dry-eye disease and a step toward regenerative medicine. This image shows a confocal image of a mouse lacrimal-gland organoid with the tear product Lcn2 labelled in red, showing that the organoids make tears. (Yorick Post, Hubrecht Institute) (CN) — Trailblazing scientists have revealed a promising future in the search for treatment of dry-eye disease by using an innovative new technique to create miniature organs call...

Date Time Researchers Find Ribosome Assembly Essential for Stem Cell Regeneration Researchers at Children’s Hospital of Philadelphia (CHOP) have identified genes responsible for hematopoietic stem cell (HSC) regeneration via the assembly of the ribosome, the protein factories in cells that translate mRNA sequences into amino acid sequences. The findings, which were published in Cell Stem Cell, highlight the importance of proper ribosome assembly in stem cell regeneration and identify possible...

A new study in mice shows how aging affects stem cells in the brain, as well as how to reactivate the production of neurons.

Using genetic engineering, researchers at UT Southwestern and Indiana University have reprogrammed scar-forming cells in mouse spinal cords to create new nerve cells, spurring recovery after spinal cord injury.

Researchers reprogram glial cells into new neurons to heal spinal cord injury Researchers at Indiana University School of Medicine have successfully reprogrammed a glial cell type in the central nervous system into new neurons to promote recovery after spinal cord injury--revealing an untapped potential to leverage the cell for regenerative medicine. The group of investigators published their findings on March 5 in Cell Stem Cell. This is the first time scientists have reported modifying NG2 g...

Mar 5, 2021 11:00am In a new study, engineering cells to overproduce Sox2 in the brains of mice generated tens of thousands of new neurons that formed connections key to restoring motor functioning after spinal cord injury.(Pixabay) Sox2 is a stem cell protein that’s known to proliferate after a spinal cord injury. Now researchers at UT Southwestern and Indiana University are proposing a method for harnessing the protein to promote healing. The researchers used genetic engineering to...