Page 36 - Cell Stem News Today

 E-Mail Boston - This year, more than 60,000 adults in the United States will be diagnosed with pancreatic cancer and, statistically, as few as 10 percent will survive five years after diagnosis, according to the American Cancer Society. Because pancreatic cancer is hidden deep within the body and often symptomless, its frequently diagnosed after the disease has progressed too far for surgical intervention and/or has spread throughout the body. Research indicates that earlier detection of panc...

Credit: IGDB A mechanistic understanding of brain development requires a systematic survey of neural progenitor cell types, their lineage specification and maturation of postmitotic neurons. Cumulative evidences based on single-cell transcriptomic analysis have revealed the heterogeneity of cortical neural progenitors, their temporal patterning and the developmental trajectories of excitatory and inhibitory neurons in the developing neocortex. Nevertheless, the developmental hierarchy of the hy...

Study reveals the mechanisms involved in the transdifferentiation of esophageal keratinocytes into columnar cells Metaplasia is defined as the replacement of a fully differentiated cell type by another. There are several classical examples of metaplasia, one of the most frequent is called Barretts esophagus. Barretts esophagus is characterized by the replacement of the keratinocytes by columnar cells in the lower esophagus upon chronic acid reflux. This metaplasia is considered a precancerous l...

 E-Mail Metaplasia is defined as the replacement of a fully differentiated cell type by another. There are several classical examples of metaplasia, one of the most frequent is called Barretts oesophagus. Barretts oesophagus is characterized by the replacement of the keratinocytes by columnar cells in the lower oesophagus upon chronic acid reflux. This metaplasia is considered a precancerous lesion that increases by around 50 times the risk of this oesophageal adenocarcinoma. Nonetheless, the ...

Do our brains age faster than the rest of our bodies? April 21, 2021USC If you feel your brain power diminishing as you advance into middle age and beyond, blame your neural stem cells. In a new study published in  Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi demonstrates that neural stem cells—the stem cells of the nervous system—age rapidly. “There is chronological aging, and there is biological aging, and they are not the same thing,” said Bonaguidi, an...

The Good Men Project Become a Premium Member We have pioneered the largest worldwide conversation about what it means to be a good man in the 21st century. Your support of our work is inspiring and invaluable. Can Restarting Aging Stem Cells Fight Memory Decline? Researchers have discovered a mechanism linked to stem cell aging as well as how to reactivate the production of neurons.   By U. Zurich As people get older, their neural stem cells lose the ability to proliferate and produce new neur...

Neural Stem Cells Decline During Aging April 14, 2021 Share Age-related disorders can be the result of stem cell dysfunction. Identifying the mechanisms that compromise stem cell behavior could be harnessed as targets to restore function. New research elucidates factors that disrupt neural stem cell (NSC)—the stem cells of the nervous system—function in the hippocampus. It also demonstrated that those NSCs are vulnerable to cellular aging. This work is published in “There is chronologic...

Credit: Albina Ibrayeva/Bonaguidi Lab In a new study published in Cell Stem Cell, a team led by USC Stem Cell scientist Michael Bonaguidi, PhD, demonstrates that neural stem cells - the stem cells of the nervous system - age rapidly. "There is chronological aging, and there is biological aging, and they are not the same thing," said Bonaguidi, an Assistant Professor of Stem Cell Biology and Regenerative Medicine, Gerontology and Biomedical Engineering at the Keck School of Medicine of USC. "W...

Brain organoid models reveal mechanisms linked to virus-induced microcephaly Researchers at IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences - demonstrate that different viruses can lead to brain malformations through diverse mechanisms by using human brain organoid models. The results are published in the journal Cell Stem Cell. Microcephaly, a term referring to developmental malformations of the fetal brain, can be caused by diverse infections during pregnancy....

Real-time imaging shines light on the coordination of neural stem cell activation In all adult vertebrates, neural stem cells can be recruited to produce new neurons in the brain. However, little is known about these so-called "activation" processes. Scientists at the Institut Pasteur, CNRS, and Tel Aviv University working in collaboration with the École Polytechnique and INRAE have successfully performed 3D visualization and spatial and temporal distribution analysis of neural stem cell activ...