Page 35 - Cell Stem News Today

 E-Mail PHILADELPHIA-- New research performed in mice models at Penn Medicine shows, mechanistically, how the infant lung regenerates cells after injury differently than the adult lung, with alveolar type 1 (AT1) cells reprograming into alveolar type 2 (AT2) cells (two very different lung alveolar epithelial cells), promoting cell regeneration, rather than AT2 cells differentiating into AT1 cells, which is the most widely accepted mechanism in the adult lung. These study findings, published to...

First stage of human embryo development created with lab-grown stem cells Human blastocysts have been created in a simple, efficient way from stem cells grown in a lab.   Scientists at the University of Exeters Living Systems Institute, in collaboration with colleagues from the University of Cambridge, have developed a method to organise lab-grown stem cells into a model of a blastocyst to recreate the first stage of human embryo development. Professor Austin Smith, director of the Living Sys...

University of Pennsylvania School of Medicine PHILADELPHIA– Human brain organoids are remarkable platforms for modeling features of human brain development and diseases. Building on methods to generate organoids to model different brain regions such as the cortex and the midbrain, researchers at the Perelman School of Medicine at the University of Pennsylvania have generated the first organoids of the arcuate nucleus (ARC), an essential structure in the hypothalamus that sends signals of hung...

Credit: Ary Marsee, Utrecht University Mini-organs or organoids play a big role in the future of medicine. Their countless applications can help develop and implement tailored therapies for each patient. The revolutionary development of organoids started in Utrecht with a group of curious scientists. But when organoid research starting booming, confusion arose. What exactly is an organoid? Are there different types, and if so, what should they be called? A group of experts from around the world...

They say the new approach unlocks news ways of studying human fertility and reproduction. Stem cells have the ability to turn into different types of cell and researchers have developed a method to organise lab-grown stem cells into an accurate model of the first stage of human embryo development. This could benefit research into infertility by furthering understanding of how embryos develop, and the conditions needed to avoid miscarriage and other complications. The embryo models can also be u...

Researchers from the UCLA School of Dentistry have discovered a key molecule that allows cancer stem cells to bypass the bodys natural immune defenses, spurring the growth and spread of head and neck squamous cell cancers. Their study, conducted in mice, also demonstrates that inhibiting this molecule derails cancer progression and helps eliminate these stem cells.

Posted Today This year, more than 60,000 adults in the United States will be diagnosed with pancreatic cancer and, statistically, as few as 10 percent will survive five years after diagnosis, according to the American Cancer Society. Because pancreatic cancer is hidden deep within the body and often symptomless, it’s frequently diagnosed after the disease has progressed too far for surgical intervention or has spread throughout the body. Research indicates that earlier detection of pancreatic...

Credit: University of Exeter Exeter scientists have discovered a simple, efficient way to recreate the early structure of the human embryo from stem cells in the laboratory. The new approach unlocks news ways of studying human fertility and reproduction. Stem cells have the ability to turn into different types of cell. Now, in research published in Cell Stem Cell and funded by the Medical Research Council, scientists at the University of Exeters Living Systems Institute, working with colleague...

Research on mouse models targets new ‘checkpoint’ that enables cancer stem cells to evade immune system UCLA School of Dentistry Head and neck cancer stem cells (red) expressing the CD276 gene (green) are found in high proportions at the periphery of tumor bodies; CD276 provides protection against cancer-fighting T cells to stem cells and interior tumor cells (blue). Brianna Aldrich | May 3, 2021 Researchers from the UCLA School of Dentistry have discovered a key molecule that a...

Researchers develop first 3D organoid models of the pancreas from human stem cells This year, more than 60,000 adults in the United States will be diagnosed with pancreatic cancer and, statistically, as few as 10 percent will survive five years after diagnosis, according to the American Cancer Society. Because pancreatic cancer is hidden deep within the body and often symptomless, its frequently diagnosed after the disease has progressed too far for surgical intervention and/or has spread throu...