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Study sheds new light on how obesity affects fat cells' mitochondria

The number of people with obesity has nearly tripled since 1975, resulting in a worldwide epidemic. While lifestyle factors like diet and exercise play a role in the development and progression of obesity, scientists have come to understand that obesity is also associated with intrinsic metabolic abnormalities.
United States San Diego University Of California San Diego Hiroyuki Hakozaki Christopher Liddle Wenmin Xia

How obesity dismantles our mitochondria

<p>UC San Diego researchers found that when mice were fed a high-fat diet, mitochondria within their fat cells broke apart and were less able to burn fat, leading to weight gain. They also found they could reverse the effect by targeting a single gene, suggesting a new treatment strategy for obesity.</p>
University Of California San Diego United States San Diego Yu Cao Yayun Xu Christopher Liddle Torrey Rhyne

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"Super-enhancer" super-charges pancreatic tum

Salk scientists identified new set of molecules that drive the growth of human pancreatic cancer cell lines, explaining how genetic mutations can activate genetic "super-enhancers" that promote out-of-control pancreatic cancer growth. They show the efficacy of an experimental drug that targets a super-enhancer related protein, demonstrating the promise of therapeutics that block the effects of super-enhancers.
New South Wales San Diego United States Salk Institute United Kingdom Elizabeth Lenkiewicz

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