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Levothyroxine does not improve heart transplantation rates in brain-dead donors

1. In this randomized crossover trial, intravenous levothyroxine, given to hemodynamically unstable brain-dead potential heart donors, did not improve the heart transplant success rates compared to placebo. 2. Levothyroxine resulted in more severe hypertension and tachycardia as compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: The majority of transplanted hearts come from brain-dead
United States Minute Medicine Inc Rating Level Confidence Interval Cardiac Surgery Heart Transplant

Recurrence is high in patients with transient atrial fibrillation during hospitalization

1. In this matched cohort study, approximately one in three patients who had transient new-onset atrial fibrillation (AF) during hospitalization had recurrent AF within one year. 2. Most study patients with recurrent AF were detected by electrocardiogram (ECG) patch monitor only. Evidence Rating Level: 1 (Excellent) Study Rundown: AF is a common arrhythmia associated with
Minute Medicine Inc Rating Level Bleeding Related Hospitalizations During Use Amiodarone With Apixaban Patients With Atrial Confidence Interval

Analyses of Kite's Yescarta® CAR T-Cell Therapy Support Curative Potential in Patients With Non-Hodgkin Lymphomas -December 11, 2023 at 09:01 pm EST

โ€“ ZUMA-1 Post-Hoc Analysis Shows Five-Year Lymphoma-Related Event-Free Survival in a Substantial Proportion of Patients with Refractory Large B-cell Lymphoma โ€“ โ€“ Four-Year Follow-up from...
United States Santa Monica Noord Holland Foster City Axicabtagene Ciloleucel Frank Neumann

Long-Term Data for Kite's Yescarta® CAR T-Cell Therapy Presented at ASH 2023 Demonstrate High Rate of Durable Response in Patients With High-Risk Large B-Cell Lymphoma -December 11, 2023 at 05:46 pm EST

โ€“ First Ever Prospective Phase 2 Study to Evaluate CAR T-Cell Therapy as First-Line Therapy Reads Out Three-Year Follow-Up Analysis โ€“ โ€“ At Median Follow-Up of 40.9 Months, Patients Treated...
United States Santa Monica Foster City Frank Neumann Julioc Chavez Gilead Company Nasdaq

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Carrier status of an actionable gene is associated with reduced life span in large Icelandic study

1. In this cross-sectional study, having carrier status of actionable genes identified by the American College of Medical Genetics and Genomics (ACMG) was associated with reduced life span compared to non-carrier status. 2. Having carrier status for an actionable cancer gene was associated with a shorter life span by an average of three years compared
American College Of Medical Genetics Minute Medicine Inc American College Medical Genetics Rating Level Confidence Interval

Five modifiable risk factors contribute to cardiovascular disease and mortality

1. In this retrospective cohort study, five risk factors (body mass index, systolic blood pressure, nonโ€“high-density lipoprotein cholesterol, current smoking, and diabetes) contributed to increased incidence of cardiovascular disease. 2. These factors were also noted to increase the risk of death from any cause. Evidence Rating Level: 2 (Good) Study Rundown: Modifiable risk factors such
World Health Organization Global Cardiovascular Risk Consortium Minute Medicine Inc Rating Level Global Cardiovascular Risk Confidence Interval

Bristol Myers Squibb Presents Primary Efficacy and Safety Analysis of the Phase 3 COMMANDS Trial of Reblozyl for Treatment of Anemia in Erythropoiesis Stimulating Agent-Naïve Patients with Lower-Risk Myelodysplastic Syndromes at ASH 2023

New data confirm findings consistent with interim analysis, reaffirming superior efficacy and significantly longer durability of response with Reblozylยฎ compared to epoetin alfa ...
United States Anne Kerber Guillermo Garcia Manero Bristol Myers Squibb European Commission American Society Of Hematology

Bristol Myers Squibb Presents Primary Efficacy and Safety Analysis of the Phase 3 COMMANDS Trial of

New data confirm findings consistent with interim analysis, reaffirming superior efficacy and significantly longer durability of response with Reblozyl® (luspatercept-aamt) compared to epoetin alfaPRINCETON, N.J.--(BUSINESS WIRE)--$BMY #ASH--Bristol Myers Squibb (NYSE: BMY) announced updated results from the primary...
United States Bristol Myers Squibb Guillermo Garcia Manero Anne Kerber Head Of Late Clinical Development European Commission

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